Description
ChemicalBook > CAS DataBase List > BAPTA-AM

BAPTA-AM

Description
Product Name
BAPTA-AM
CAS No.
126150-97-8
Chemical Name
BAPTA-AM
Synonyms
CS-968;BAPTA-AM;DAPTA-AM;BAPTA AM, >=98%;BAPTA/AM(BAPTA-AM);BAPTA, AM *CAS 126150-97-8*;BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM;BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER;Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate
CBNumber
CB0461324
Molecular Formula
C34H40N2O18
Formula Weight
764.68
MOL File
126150-97-8.mol
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BAPTA-AM Property

Melting point:
86-90°C
Boiling point:
796.1±60.0 °C(Predicted)
Density 
1.350±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in chloroform, dimethyl sulfoxide
form 
powder
pka
1.69±0.50(Predicted)
color 
White
λmax
287 nm
BRN 
7458534
Stability:
Light Sensitive
Biological Applications
Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions
InChIKey
YJIYWYAMZFVECX-UHFFFAOYSA-N
CAS DataBase Reference
126150-97-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
8-10-21
HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1076
Product name
BAPTA-AM
Purity
≥95% (HPLC)
Packaging
25mg
Price
$281
Updated
2024/03/01
Sigma-Aldrich
Product number
196419
Product name
BAPTA/AM - CAS 126150-97-8 - Calbiochem
Purity
Membrane-permeable form of BAPTA.
Packaging
25MG
Price
$258
Updated
2024/03/01
Sigma-Aldrich
Product number
196419
Product name
BAPTA/AM - CAS 126150-97-8 - Calbiochem
Purity
Membrane-permeable form of BAPTA.
Packaging
100mg
Price
$619
Updated
2022/05/15
TCI Chemical
Product number
T2845
Product name
Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
Packaging
20MG
Price
$117
Updated
2024/03/01
TCI Chemical
Product number
T2845
Product name
Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
Packaging
200MG
Price
$693
Updated
2024/03/01
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BAPTA-AM Chemical Properties,Usage,Production

Description

BAPTA-AM is a selective, membrane-permeable calcium chelator.

Description

BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge.1,2 Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases. Pretreatment of cells with BAPTA-AM inhibits thapsigargin-induced responses.3

Chemical Properties

Off-White to Light Yellow Solid

Uses

A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.

Uses

BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).

Uses

A cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Uses

BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Definition

ChEBI: 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester is an alpha-amino acid ester.

General Description

BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+?channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786 ). Blocks hK v 1.5, hERG and hK v 1.3 channels (K i values are 1.23, 1.30 and 1.45 μ M respectively). Displays antithrombotic activity in vitro .

Biochem/physiol Actions

Selective chelator of intracellular Ca2+ stores.

storage

-20°C

References

1) Smith et al. (1992), Cytosolic calcium as a second messenger for collagen-induced platelet responses; Biochem. J., 288 925 2) Yoshida et al. (1993), Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells; Biochem. Biophys. Res. Commun., 196 927 3) Jiang et al. (1994), Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin; Exp. Cell Res., 212 84

BAPTA-AM Preparation Products And Raw materials

Raw materials

Preparation Products

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BAPTA-AM Suppliers

Canada 1 China 131 Europe 2 Germany 2 India 3 Japan 4 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 7 United States 31 Global 185
Hefei NaNo Biological Technology Co., Ltd.
Tel
0551-65629887 18010855303
Fax
0551-65629887
Email
sales@hfnhsw.com
Country
China
ProdList
261
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58
Shanghai Tube Pharmaceutical Co., Ltd.
Tel
021-54338626 18017892860
Fax
021-54338626
Email
sales@tubepharm.com
Country
China
ProdList
2416
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
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View Lastest Price from BAPTA-AM manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
BAPTA-AM 126150-97-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

126150-97-8, BAPTA-AMRelated Search:

Fluo 3-AM BAPTA Fura 2-AM BAPTA-AM RHOD-2, AM 5,5'-DIFLUORO BAPTA, AM NITR 5/AM 5,5'-DIBROMO BAPTA AM INDO 1-AM BAPTA-AM 5 5'-DIFLUOR-BAPTA-AM 1,2.BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID, TETRAACETOXYMETHYL ESTER; BAPTA-AM 4,4'-Difluoro-BAPTA-AM 5,5I DIFLUORO BAPTA(AM) BAPTA, AM *UltraPure Grade* 5,5'-Dimethl-BAPTA-AM 5,5'-DIMETHYL BAPTA, AM 5,5'-DINITRO BAPTA, AM

  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER
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  • BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM
  • CS-968
  • BAPTA/AM(BAPTA-AM)
  • acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
  • 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid Tetrakis(acetoxymethyl Ester)
  • Glycine, n,n0-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[n-[2- [(acetyloxy)methoxy]-2-oxoethyl]-, Bis[(acetyloxy)methyl] ester
  • BAPTA, AM *CAS 126150-97-8*
  • BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*
  • DAPTA-AM
  • 1,2-BIS (2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID, TETRAACETOXYMETHYL ESTER
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXY-METHYL) ESTER
  • 1,2-BIS(O-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID TETRA(ACETOXYMETHYL) ESTER
  • O,O'-Bis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraaceticacid,tetraacetoxymethylester
  • 1,2-Bis(2-aminophenoxy)ethane-N,N,N'',N''-tetraacetic acid<br>tetrakis(acetoxymethyl ester)
  • N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)Methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)Methyl] Ester
  • 1,2-Bis(2-aMinophenoxy)ethane-N,N,N`,N`-tetraacetic acid tetrakis(acetoxyMethyl ester), (BAPTA AM)
  • Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate
  • Tetrakis(acetoxyMethyl) 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetate
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER(BAPTA-AM)
  • BAPTA-AM 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
  • BAPTA AM, >=98%
  • BAPTA, AM ester [1,2- Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester]
  • O,O'-Bis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraacetic Acid, Tetraacetoxymethyl Ester 50mM/l
  • Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester
  • Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester
  • 126150-97-8
  • C34H40N2O18
  • Intracellular Calcium Signaling
  • BioChemical
  • Cell Signaling and Neuroscience
  • Calcium Signaling Research Tools
  • Calcium Chelators
  • Cell Biology
  • Aromatic
  • Inhibitors
  • Chelating Agents & Ligands
  • Fluorescent Labels & Indicators
  • Amines
  • Aromatics