NAV2729

Product Name: NAV2729
CAS No.: 419547-11-8
Chemical Name: NAV2729
Synonyms: NAV2729;CS-2790;Grassofermata;NAV-2729 ，E1047;NAV-2729;NAV2729;Grassofermata，NAV2729;NAV-2729 >=98% (HPLC);NAV-2729, 10 mM in DMSO;Inhibitor,NAV-2729,inhibit,NAV2729,NAV 2729;2-Benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CBNumber: CB04629487
Molecular Formula: C25H17ClN4O3
Formula Weight: 456.88
MOL File: 419547-11-8.mol

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NAV2729 Property

Boiling point:: 678.0±65.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 2 mg/ml
form: A crystalline solid
pka: -2.43±0.40(Predicted)
color: Light yellow to yellow
InChI: 1S/C25H17ClN4O3/c26-19-10-6-18(7-11-19)24-22(14-16-4-2-1-3-5-16)28-29-23(31)15-21(27-25(24)29)17-8-12-20(13-9-17)30(32)33/h1-13,15,27H,14H2
InChIKey: GUUWHOSUKOCRHG-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C([N+]([O-])=O)C=C2)NC3=C(C4=CC=C(Cl)C=C4)C(CC5=CC=CC=C5)=NN31

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Safety

WGK Germany: WGK 3
HS Code: 2933998090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2238
Product name: NAV-2729
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $104.28
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2238
Product name: NAV-2729
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $423
Updated: 2025/07/31

Cayman Chemical

Product number: 26202
Product name: NAV2729
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26202
Product name: NAV2729
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 26202
Product name: NAV2729
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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NAV2729 Chemical Properties,Usage,Production

Uses

NAV 2729 is a selective ARF6 inhibitor.

Definition

ChEBI: NAV2729 is a pyrazolopyrimidine that is 4H-pyrazolo[1,5-a]pyrimidin-7-one which is substituted at positions 2, 3, and 5 by benzyl, p-chlorophenyl, and p-nitrophenyl groups, respectively. It is an inhibitor of ADP-ribosylation factor 6 (ARF6), a member of the ADP ribosylation factor family of GTP-binding proteins. It has a role as an inhibitor. It is a pyrazolopyrimidine, a C-nitro compound and a member of monochlorobenzenes.

Biological Activity

NAV-2729 (IC50 of\u20091.5\u2009μM) has a therapeutic benefit in reducing the adverse effect of diabetic retinopathy in animal models.', 'Originally characterized as a non-nucleotide-competitive and reversible ARF6-selective inhibitor (IC50 = 1.4 μM without GEF and 2.4 μM with 100 nM ARNO or BRAG2/GEP100) th at targets ARF6 GEF-binding region, NAV-2729 prevents GEF-dependent ARF1 & ARF6 activity (% inhibition of BRAG2Sec7PH-stimulated GTPase activity/[NAV-2729] = 50% Δ17Arf1/10 μM and 15% Δ13Arf6/25 μM) with higher potency against BRAG2- than ARNO-dependent ARF1 activity (64% vs. 20% Δ17Arf1 inhibition at 25 μM in the presence of respective GEF sec7 domain). NAV-2729 treatment effectively inhibits G-alpha-q downstream signaling pathways and anchorage-independent colony growth of Mel92.1 & Mel202 melanoma cells in vitro (10 μM) as well as uveal melanoma tumor establishment in Mel202 xenograft mice in vivo (30 mg/kg/day i.p.).

in vivo

Systemic treatment of mice with NAV-2729 interfere with tumorigenesis and tumor growth in orthotopic xenograft mouse model of uveal melanoma^[1].

storage

Store at +4°C

NAV2729 Preparation Products And Raw materials

Raw materials

Preparation Products

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NAV2729 Suppliers

China 69 India 1 United Kingdom 1 United States 8 USA 1 Global 80

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
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419547-11-8, NAV2729Related Search:

NAV2729

3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Grassofermata

NAV-2729;NAV2729

CS-2790

Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 3-(4-chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)-

NAV-2729 >=98% (HPLC)

Grassofermata，NAV2729

2-Benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Inhibitor,NAV-2729,inhibit,NAV2729,NAV 2729

NAV-2729, 10 mM in DMSO

NAV-2729 ，E1047

419547-11-8