3,5-DICHLOROSALICYLALDEHYDE

Product Name: 3,5-DICHLOROSALICYLALDEHYDE
CAS No.: 90-60-8
Chemical Name: 3,5-DICHLOROSALICYLALDEHYDE
Synonyms: NSC 96393;AKOS B029257;TIMTEC-BB SBB003642;3,5-dichlorosalicyde;LABOTEST-BB LT00089371;3,5-DICHLORO SALICYLAL;Dichlorosalicylaldehyde;5-Dichlorosalicylaldehyde;3,5-Dichlorosalicyladehyde;3,5-dichlorosalicyaldehyde
CBNumber: CB0465403
Molecular Formula: C7H4Cl2O2
Formula Weight: 191.01
MOL File: 90-60-8.mol

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3,5-DICHLOROSALICYLALDEHYDE Property

Melting point:: 95-97 °C (lit.)
Boiling point:: 273.68°C (rough estimate)
Density: 1.4410 (rough estimate)
refractive index: 1.4590 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: ethanol: soluble5%, clear, faintly yellow to greenish-yellow
form: Crystalline Powder
pka: 6.27±0.23(Predicted)
color: Pale yellow
Water Solubility: Insoluble in water. Solubility in methanol is almost transparent.
Sensitive: Air Sensitive
BRN: 973391
InChI: InChI=1S/C7H4Cl2O2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H
InChIKey: FABVMBDCVAJXMB-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(Cl)=CC(Cl)=C1O
CAS DataBase Reference: 90-60-8(CAS DataBase Reference)
EPA Substance Registry System: Benzaldehyde, 3,5-dichloro-2-hydroxy- (90-60-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29121900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 261815
Product name: 3,5-Dichlorosalicylaldehyde
Purity: 99%
Packaging: 5g
Price: $37.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 261815
Product name: 3,5-Dichlorosalicylaldehyde
Purity: 99%
Packaging: 25g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: D1170
Product name: 3,5-Dichlorosalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: D1170
Product name: 3,5-Dichlorosalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $76
Updated: 2025/07/31

TRC

Product number: D432310
Product name: 3,5-Dichlorosalicylaldehyde
Packaging: 25g
Price: $60
Updated: 2021/12/16

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3,5-DICHLOROSALICYLALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

pale yellow crystalline powder

Uses

3,5-Dichlorosalicylaldehyde has been used in the preparation of Schiff base ligands and (RS)-3,5-dichloro-2-[[(1-phenylethyl)imino]methyl]phenol.

Uses

3,5-Dichlorosalicylaldehyde has been used in the preparation of:

Schiff base ligands
(RS)-3,5-dichloro-2-[[(1-phenylethyl)imino]methyl]phenol

Synthesis

100-97-0

120-83-2

90-60-8

The general procedure for the synthesis of 3,5-dichlorosalicylaldehyde from urotropine and 2,4-dichlorophenol was as follows: first, 2,4-dichlorophenol (10.0 g, 61.3 mmol) and hexamethylenetetetramine (17.2 g, 122.6 mmol) were dissolved in 80 mL of methanesulfonic acid, and the reaction mixture was heated and stirred for 1.5 hours at 100 °C. After the reaction was completed, the reaction mixture was diluted with ethyl acetate, and the organic layer was washed sequentially with water and saturated sodium bicarbonate solution, and then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography using ethyl acetate/hexane gradient elution to afford the target compound 3,5-dichloro-2-hydroxybenzaldehyde (INT-01) as a yellow oil (7.5 g, 64% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ11.39 (s, 1H), 7.64 (s, 1H), 7.52 (s, 1H). Liquid chromatography (LC) analytical conditions: C-18 column, 5 min to 95% acetonitrile/water gradient elution, flow rate 1.7 mL/min, detection wavelength 254 nm, column temperature 23 ℃, retention time (tr) = 3.95 min.

References

[1] Patent: WO2015/109011, 2015, A1. Location in patent: Paragraph 0205; 0206
[2] Patent: WO2015/109014, 2015, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: US2015/197500, 2015, A1. Location in patent: Paragraph 0263; 0264
[4] Chemical & Pharmaceutical Bulletin, 1983, vol. 31, # 5, p. 1751 - 1753
[5] Journal of the Chemical Society, 1941, p. 547,549

3,5-DICHLOROSALICYLALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DICHLOROSALICYLALDEHYDE Suppliers

Americas 1 Belgium 4 China 224 Europe 3 Germany 5 India 14 Japan 4 Slovakia 1 Switzerland 3 Ukraine 2 United Kingdom 20 United States 45 Global 326

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View Lastest Price from 3,5-DICHLOROSALICYLALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-DICHLOROSALICYLALDEHYDE 90-60-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-11

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-Dichlorosalicylaldehyde 90-60-8
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3,5-DICHLOROSALICYLALDEHYDE 90-60-8
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

90-60-8, 3,5-DICHLOROSALICYLALDEHYDERelated Search:

3,5,6-Trichlorosalicylic acid 6,8-DICHLORO-3-FORMYLCHROMONE 3,5-DICHLOROSALICYLALDEHYDE 3,5-Dichlorosalicylic acid 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 3,3',4',5-TETRACHLOROSALICYLANILIDE S(-)-RACLOPRIDE L-TARTRATE 3,5-DICHLORO-2,6-DIMETHOXYBENZOIC ACID CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG 4,6-DICHLOROSALICYLALDEHYDE Salicylaldehyde 3,5-DICHLORO-2-METHOXYBENZOIC ACID 1-(3,5-DICHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE OXALIC ACID BIS[2,4,5-TRICHLORO-6-(PENTYLOXYCARBONYL)PHENYL] ESTER ETHYL 2-(2,4-DICHLORO-6-FORMYLPHENOXY)ACETATE 6,8-Dichloro Chromone 6,8-DICHLORO-3-CYANOCHROMONE 6,8-DICHLORO-3-METHYLCHROMONE

Benzaldehyde,3,5-dichloro-2-hydroxy-

Salicylaldehyde, 3,5-dichloro-

Salicylaldehyde,3,5-dichloro-

AKOS B029257

3,5-DICHLORO SALICYLAL

3,5-DICHLOROSALICYLALDEHYDE

3,5-DICHLORO-2-HYDROXYBENZALDEHYDE

LABOTEST-BB LT00089371

3,5-dichlorosalicyde

3,5-Dichlorosalicyladehyde

3,5-Dichlorosalicylaldehyde, 98+%

3,5-dichlorosalicyaldehyde

3,5-DICHLORO-2-HYDROBENZALDEHYDE

3,5-Dichloro-2-hydroxybenzaldehyde, 97+%

5-Dichlorosalicylaldehyde

3,5-Dichlorosalicylaldehyde, 98+% 5GR

NSC 96393

3,5-Dichlorosalicylaldehyde 99%

Dichlorosalicylaldehyde

3,5-Dichlorosalicylaldehyde[3,5-Dichloro-2-hydroxybenzaldehyde]

TIMTEC-BB SBB003642

2-Hydroxy-3,5-dichlorobenzaldehyde

3,5-dichloro-2-hydroxy-benzaldehyd

2-(1-iminoethoxy)ethanesulfonic acid

3,5-Dichlorosalicylaldehyde &gt

3,5-Dichloro-3-fluoroacetophenone

90-60-8

Cl2C6H2OHCHO

Organic Building Blocks

ALDEHYDE

C7

Carbonyl Compounds

Building Blocks

Aldehydes

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Aldehydes

C7

Carbonyl Compounds