incb057643
- Product Name
- incb057643
- CAS No.
- 1820889-23-3
- Chemical Name
- incb057643
- Synonyms
- INCB;CS-2906;incb057643;INCB-057643, 10 mM in DMSO;INCB057643,Apoptosis,Epigenetic Reader Domain,inhibit,INCB 057643,INCB-057643,Inhibitor;2H-1,4-Benzoxazin-3(4H)-one, 8-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-2,2,4-trimethyl-6-(methylsulfonyl)-;2,2,4-Trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
- CBNumber
- CB04661175
- Molecular Formula
- C20H21N3O5S
- Formula Weight
- 415.46
- MOL File
- 1820889-23-3.mol
incb057643 Property
- Boiling point:
- 787.7±60.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
- form
- A crystalline solid
- pka
- 14.74±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 31456
- Product name
- INCB 057643
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $69
- Updated
- 2026/04/30
- Product number
- 31456
- Product name
- INCB 057643
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $263
- Updated
- 2026/04/30
- Product number
- 31456
- Product name
- INCB 057643
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $393
- Updated
- 2026/04/30
- Product number
- 31456
- Product name
- INCB 057643
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $655
- Updated
- 2026/04/30
- Product number
- orb573362
- Product name
- INCB057643
- Purity
- >98%
- Packaging
- 100mg
- Price
- $986
- Updated
- 2021/12/16
incb057643 Chemical Properties,Usage,Production
Uses
INCB-057643, is a novel, orally bioavailable BET inhibitor.
in vivo
Production of several cytokines, including IL-6, IL-10 and MIP-1α, is repressed by INCB-057643 in human and mouse whole blood stimulated ex vivo with LPS. Oral administration of INCB-057643 results in significant anti-tumor efficacy in xenograft models of AML, myeloma, and DLBCL. Additionally, combining INCB-057643 with standard of care agents used for the treatment of DLBCL including rituximab and bendamustine results in enhanced anti-tumor efficacy relative to that achieved with single agent therapies at doses that are well tolerated[1].
incb057643 Preparation Products And Raw materials
Raw materials
Preparation Products
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