A-395

Product Name: A-395
CAS No.: 2089148-72-9
Chemical Name: A-395
Synonyms: A-395;A-395, 10 mM in DMSO;A-395,Histone Methyltransferase,A395,A 395,Inhibitor,inhibit;(3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine;3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)-
CBNumber: CB04667470
Molecular Formula: C26H35FN4O2S
Formula Weight: 486.65
MOL File: 2089148-72-9.mol

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A-395 Property

Boiling point:: 612.2±65.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (205.49 mM)
form: Solid
pka: 8.49±0.40(Predicted)
color: White to yellow
Water Solubility: H2O: 10mg/mL, clear

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0021615
Product name: A-395
Purity: 99.31%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0021615
Product name: A-395
Purity: 99.31%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0021615
Product name: A-395
Purity: 99.31%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

DC Chemicals

Product number: DC10129
Product name: A395
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC10129
Product name: A395
Purity: >98%
Packaging: 250mg
Price: $1750
Updated: 2021/12/16

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A-395 Chemical Properties,Usage,Production

Biological Activity

A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nM, inhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27, and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nM, inhibiting the formation of H3K27me3. For characterization details of A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.

A-395N is the negative control for the active enantiomer, A-395. A-395N is available from Sigma. To learn more about and purchase A-395N, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

A-395 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-395 Suppliers

China 21 United States 2 Global 23

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2089148-72-9, A-395Related Search:

A-395

3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)-

A-395,Histone Methyltransferase,A395,A 395,Inhibitor,inhibit

(3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine

A-395, 10 mM in DMSO

2089148-72-9