APX-115

Product Name: APX-115
CAS No.: 1395946-75-4
Chemical Name: APX-115
Synonyms: APX-115;Ewha-18278;APX-115 HCl;APX-115 (Ewha 18278;APX-115, 10 mM in DMSO;3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride
CBNumber: CB04667546
Molecular Formula: C17H18ClN3O
Formula Weight: 315.8
MOL File: 1395946-75-4.mol

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APX-115 Property

form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0079216
Product name: APX-115
Purity: >98.0%
Packaging: 1mg
Price: $335
Updated: 2021/12/16

Axon Medchem

Product number: Axon2819
Product name: APX-115-Ewha-18278
Purity: 99%
Packaging: 2x25mg
Price: $660
Updated: 2021/12/16

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APX-115 Chemical Properties,Usage,Production

Uses

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1].

in vivo

APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice^[2].
APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels^[2].

Animal Model:	Six-week-old male diabetic db/db mice (C57BLKS/J-lepr^db/lepr^db)^[2]
Dosage:	60mg/kg
Administration:	Oral gavage; per day; for 12 weeks
Result:	Significantly improved insulin resistance in diabetic mice.

IC 50

NOX1; NOX2; NOX4

References

[1] Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. DOI:10.18632/oncotarget.18540
[2] Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. DOI:10.1038/labinvest.2017.2

APX-115 Preparation Products And Raw materials

Raw materials

Preparation Products

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APX-115 Suppliers

China 26 United States 6 Global 32

BOC Sciences

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1395946-75-4, APX-115Related Search:

APX-115

Ewha-18278

3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride

APX-115 HCl

APX-115, 10 mM in DMSO

APX-115 (Ewha 18278

1395946-75-4