AZD3229

Product Name: AZD3229
CAS No.: 2248003-60-1
Chemical Name: AZD3229
Synonyms: AZD3229;AZD3229 (AZD-3229;AZD3229, 10 mM in DMSO;AZD3229;AZD 3229;AZD-3229;Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit;1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-
CBNumber: CB04667591
Molecular Formula: C24H26FN7O3
Formula Weight: 479.51
MOL File: 2248003-60-1.mol

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AZD3229 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:68.67(Max Conc. mg/mL);143.21(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.85(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.63(Max Conc. mM)
form: A crystalline solid
pka: 12.75±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 5mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 1mg
Price: $130
Updated: 2024/03/01

ChemScene

Product number: CS-0065717
Product name: AZD3229
Purity: 99.55%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573321
Product name: AZD3229
Purity: >98%
Packaging: 250mg
Price: $1949.9
Updated: 2021/12/16

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AZD3229 Chemical Properties,Usage,Production

Biological Activity

AZD3229 is a potent pan-Kit (c-Kit) mutant inhibitor with GI50 of 1-50 nM in a Kit (c-Kit) mutant-driven Ba/F3 cell line. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).

in vivo

AZD3229 has high bioavailability, low clearance and small volume of distribution in preclinical animal models of mice, rats and dogs. In an in vivo model constructed using the Ba/F3 cell line, AZD3229 at 20 mg/kg bid induces regression of tumor volume more effectively than regorafenib and imatinib at 100 mg/kg qd.

target

Target	Value
Kit ()
PDGFRα ()
PDGFRβ ()

AZD3229 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD3229 Suppliers

China 23 United States 5 Global 28

Sichuan Wei Keqi Biological Technology Co., Ltd.

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Energy Chemical

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2248003-60-1, AZD3229Related Search:

AZD3229

AZD3229 (AZD-3229

AZD3229;AZD 3229;AZD-3229

Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit

1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-

AZD3229, 10 mM in DMSO

2248003-60-1