ChemicalBook > CAS DataBase List > CD38 inhibitor 78c
CD38 inhibitor 78c
- Product Name
- CD38 inhibitor 78c
- CAS No.
- 1700637-55-3
- Chemical Name
- CD38 inhibitor 78c
- Synonyms
- 78c;cd38-1;MDK7553;MDK 7553;MDK-7553;CD38i_78c;CD38IN-78c;CD38 IN-78c;CD38-IN-78c;Compound-78c
- CBNumber
- CB04667733
- Molecular Formula
- C22H27N3O3S
- Formula Weight
- 413.53
- MOL File
- 1700637-55-3.mol
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CD38 inhibitor 78c Property
- Boiling point:
- 589.8±50.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
- form
- A solid
- pka
- 3.17±0.20(Predicted)
- color
- Light yellow to brown
- InChI
- InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
- InChIKey
- VJQALSOBHVEJQM-QAQDUYKDSA-N
- SMILES
- N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O
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N-Bromosuccinimide Price
TRC
- Product number
- M349560
- Product name
- 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
- Packaging
- 1mg
- Price
- $370
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20332
- Product name
- CD38inhibitor78c
- Purity
- >98%
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20332
- Product name
- CD38inhibitor78c
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1400
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20332
- Product name
- CD38inhibitor78c
- Purity
- >98%
- Packaging
- 1g
- Price
- $2800
- Updated
- 2021/12/16
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CD38 inhibitor 78c Chemical Properties,Usage,Production
Description
Thiazoloquin(az)olin(on)es, such as the small molecule 78c, have been identified as potent CD38 inhibitors (CD38i). CD38 inhibitor 78c is a potent, reversible, and uncompetitive inhibitor of CD38. 78c reverses age-related NAD+ decline and ameliorates several metabolic, structural, and molecular ageing features in chronologically aged and progeroid mice. The CD38 inhibitor 78c increases naturally aged mice's lifespan and health span. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between the sexes[1-2].
Uses
4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone is a useful compound and has been evaluated for use as CD38 inhibitors.
storage
Store at -20°C
References
[1] Thais R. Peclat. “CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.” Aging Cell 21 4 (2022).
[2] Mariana G Tarragó. “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.” Cell metabolism 27 5 (2018): 1081-1095.e10.
CD38 inhibitor 78c Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CD38 inhibitor 78c manufacturers
Hubei Chuchang Biotech Co., Ltd.
- Product
- CD38 1700637-55-3
- Price
- US $0.00-0.00/mg
- Min. Order
- 1mg
- Purity
- 98
- Supply Ability
- 100G
- Release date
- 2024-04-17