GeA-69

Product Name: GeA-69
CAS No.: 2143475-98-1
Chemical Name: GeA-69
Synonyms: eA-69;GeA-69;GeA-69 >=98% (HPLC);GeA-69, 10 mM in DMSO;N-(2-(9H-Carbazol-1-yl)phenyl)acetamide;Acetamide, N-[2-(9H-carbazol-1-yl)phenyl]-;PARP,HeLa,GeA-69,U-2 OS,GeA69,cytotoxicity,DNA damage repair mechanism,intact cell,Inhibitor,cell permeable,GeA 69,inhibit,poly ADP ribose polymerase,HEK293
CBNumber: CB04667935
Molecular Formula: C20H16N2O
Formula Weight: 300.35
MOL File: 2143475-98-1.mol

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GeA-69 Property

Boiling point:: 568.3±25.0 °C(Predicted)
Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO:92.5(Max Conc. mg/mL);307.96(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);33.29(Max Conc. mM)
pka: 14.96±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030139
Product name: GeA-69
Purity: 99.69%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CR1-3706-M001
Product name: GeA-69
Purity: ≥95%
Packaging: 1mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0030139
Product name: GeA-69
Purity: 99.69%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0030139
Product name: GeA-69
Purity: 99.69%
Packaging: 25mg
Price: $260
Updated: 2021/12/16

Axon Medchem

Product number: Axon2885
Product name: GeA-69
Purity: 99%
Packaging: 50mg
Price: $418
Updated: 2021/12/16

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GeA-69 Chemical Properties,Usage,Production

Uses

GeA-69 is a cell-permeable, selective allosteric inhibitor targeting macrodomain 2 (MD2) of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14).

Biological Activity

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

storage

Store at -20°C

GeA-69 Preparation Products And Raw materials

Raw materials

Preparation Products

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GeA-69 Suppliers

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2143475-98-1, GeA-69Related Search:

GeA-69

eA-69

Acetamide, N-[2-(9H-carbazol-1-yl)phenyl]-

GeA-69 >=98% (HPLC)

N-(2-(9H-Carbazol-1-yl)phenyl)acetamide

PARP,HeLa,GeA-69,U-2 OS,GeA69,cytotoxicity,DNA damage repair mechanism,intact cell,Inhibitor,cell permeable,GeA 69,inhibit,poly ADP ribose polymerase,HEK293

GeA-69, 10 mM in DMSO

2143475-98-1