ChemicalBook > CAS DataBase List > GNE-781

GNE-781

Product Name: GNE-781
CAS No.: 1936422-33-1
Chemical Name: GNE-781
Synonyms: GNE-781;GNE-781, 10 mM in DMSO;GNE-781,Histone Acetyltransferase,Inhibitor,HATs,Epigenetic Reader Domain,GNE 781,HAT,inhibit,GNE781;3- (7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3.4-dihydro-2H-quinohn-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4.3-c]pyridine-5-carboxamide;3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide;5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-
CBNumber: CB04667955
Molecular Formula: C27H33F2N7O2
Formula Weight: 525.59
MOL File: 1936422-33-1.mol

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GNE-781 Property

Melting point:: 135-140oC
Boiling point:: 800.7±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 14.19±0.20(Predicted)
form: Solid
color: White to Pale Yellow
InChIKey: CQCWHSDMJBAGDC-UHFFFAOYSA-N
SMILES: C1N(C(NC)=O)CCC2N(C3CCOCC3)N=C(N3C4=C(C=C(C5=CN(C)N=C5)C(C(F)F)=C4)CCC3)C1=2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D447825
Product name: GNE-781
Packaging: 5mg
Price: $1465
Updated: 2021/12/16

ChemScene

Product number: CS-0030034
Product name: GNE-781
Purity: 98.19%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0030034
Product name: GNE-781
Purity: 98.19%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0030034
Product name: GNE-781
Purity: 98.19%
Packaging: 100mg
Price: $3350
Updated: 2021/12/16

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GNE-781 Chemical Properties,Usage,Production

Uses

GNE-781 is a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.

in vivo

GNE-781 (3-30 mg/kg; p.o.; twice daily for 21 days) has tumor growth inhibition (%TGI) is 73%, 71%, and 89% at 3, 10, and 30 mg/kg, respectively in SCID beige mice with MOLM-16 AML xenografts^[1].
? GNE-781 decreases Foxp3 transcript levels in a dose dependent manner. GNE-781 (3-30 mg/kg) suppresses MYC at doses as low as 3 mg/kg at 2 and 8 h, with maximal suppression at 10 and 30 mg/kg at 2 h (87% and 88% inhibition, respectively)^[1].

GNE-781 Preparation Products And Raw materials

Raw materials

Preparation Products

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1936422-33-1, GNE-781Related Search:

GNE-781

5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-

3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

3- (7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3.4-dihydro-2H-quinohn-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4.3-c]pyridine-5-carboxamide

GNE-781,Histone Acetyltransferase,Inhibitor,HATs,Epigenetic Reader Domain,GNE 781,HAT,inhibit,GNE781

GNE-781, 10 mM in DMSO

1936422-33-1

1396422-33-1

C27H33F2N7O2