PF-06761281
- Product Name
- PF-06761281
- CAS No.
- 1854061-19-0
- Chemical Name
- PF-06761281
- Synonyms
- PF-06761281;PF-06761281 >=97% (HPLC);Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
- CBNumber
- CB04670535
- Molecular Formula
- C13H17NO6
- Formula Weight
- 283.28
- MOL File
- 1854061-19-0.mol
PF-06761281 Property
- Boiling point:
- 469.7±45.0 °C(Predicted)
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- powder
- pka
- 3.37±0.28(Predicted)
- color
- white to beige
Safety
- RIDADR
- UN 2811 6.1 / PGIII
N-Bromosuccinimide Price
- Product number
- PZ0318
- Product name
- PF-06761281
- Purity
- ≥97% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- PZ0318
- Product name
- PF-06761281
- Purity
- ≥97% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
PF-06761281 Chemical Properties,Usage,Production
Uses
PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.
General Description
PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.
Biochem/physiol Actions
PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.
PF-06761281 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06761281 Suppliers
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