ChemicalBook > CAS DataBase List > c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS

c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS

Product Name
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
CAS No.
1638750-95-4
Chemical Name
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
Synonyms
ADUS100 sodium;ADU-S100 (MIW815);MIW815 disodium salt;ML RR-S2 CDA disodium;ADU-S100 disodium salt;ML RR-S2 CDA Sodium Salt;ML RR-S2 CDA disodium salt;c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS;c[A(2′,,5′,)pS[Rp]-A(3′,,5′,)pS[Rp]];ADUS100 disodium salt,ADU S100 disodium salt,ADU-S-100 disodium salt
CBNumber
CB04670984
Molecular Formula
C20H25N10NaO10P2S2
Formula Weight
714.54
MOL File
1638750-95-4.mol
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c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS Property

storage temp. 
Store at -20°C
solubility 
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Water: Sparingly soluble: 1-10 mg/ml
form 
Solid
color 
White to off-white
Water Solubility 
Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016503
Product name
ADU-S100disodiumsalt
Purity
98.83%
Packaging
1mg
Price
$195
Updated
2021/12/16
ChemScene
Product number
CS-0016503
Product name
ADU-S100disodiumsalt
Purity
98.83%
Packaging
5mg
Price
$645
Updated
2021/12/16
ChemScene
Product number
CS-0016503
Product name
ADU-S100disodiumsalt
Purity
98.83%
Packaging
10mg
Price
$1150
Updated
2021/12/16
ChemScene
Product number
CS-0016503
Product name
ADU-S100disodiumsalt
Purity
98.83%
Packaging
25mg
Price
$2400
Updated
2021/12/16
ChemScene
Product number
CS-0016503
Product name
ADU-S100disodiumsalt
Purity
98.83%
Packaging
50mg
Price
$4200
Updated
2021/12/16
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c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS Chemical Properties,Usage,Production

Uses

ML RR-S2 CDA sodium salt is used as a cyclic dinucleotide used in the treatment of cancer. It activates dendritic cells which induces a specific T-cell mediated immune response against cancer cells.

in vivo

2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].

References

[1] LETICIA CORRALES. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.[J]. Cell reports, 2015, 11 7: 1018-1030. DOI: 10.1016/j.celrep.2015.04.031
[2] GILLES BERGER. STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 28: e2111003119. DOI: 10.1073/pnas.2111003119

c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS Preparation Products And Raw materials

Raw materials

Preparation Products

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c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS Suppliers

China 33 India 1 United States 6 Global 40
BOC Sciences
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16314854226
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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Sales@ATKchemical.com
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Fan De(Beijing) Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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HUNAN CHEMFISH SCIENTIFIC CO.,LTD
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Guangzhou Younan Technology Co., Ltd
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1638750-95-4, c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSSRelated Search:


  • c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
  • ADU-S100 (MIW815)
  • ADU-S100 disodium salt
  • ML RR-S2 CDA disodium salt
  • MIW815 disodium salt
  • ML RR-S2 CDA Sodium Salt
  • ADUS100 sodium
  • ADUS100 disodium salt,ADU S100 disodium salt,ADU-S-100 disodium salt
  • (2R,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7,14-Bis(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-dimercaptooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11]pentaoxa[2,10]diphosphacyclotetradecine 2,10-dioxide disodium salt
  • c[A(2&#8242,,5&#8242,)pS[Rp]-A(3&#8242,,5&#8242,)pS[Rp]]
  • ML RR-S2 CDA disodium
  • 1638750-95-4
  • Nucleotide