AGI-24512

Product Name: AGI-24512
CAS No.: 2201066-53-5
Chemical Name: AGI-24512
Synonyms: AGI-24512;6-(4-Hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one;Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(1-piperidinyl)-;Inhibitor,inhibit,DNA damage response,anticancer,methylthioadenosine phosphorylase,AGI 24512,Methionine Adenosyltransferase (MAT),PRMT5,AGI24512,AGI-24512,antiproliferative,MTAP,HCT116,S-adenosylmethionine Synthetase,MAT2A
CBNumber: CB04672630
Molecular Formula: C24H24N4O2
Formula Weight: 400.47
MOL File: 2201066-53-5.mol

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AGI-24512 Property

Boiling point:: 639.3±65.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (312.13 mM);Water : < 0.1 mg/mL (insoluble)
pka: 9.47±0.30(Predicted)
form: Solid
color: White to gray

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Hazard and Precautionary Statements (GHS)

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AGI-24512 Chemical Properties,Usage,Production

Description

AGI-24512 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-24512 showed in vivo activity in MTAP null tumors.

Uses

AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1].

in vivo

AGI-24512 shows poor oral absorption and a short half-life in rats^[2].

References

[1] Kalev P, et al. MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage. Cancer Cell. 2021 Feb 8;39(2):209-224.e11. DOI:10.1016/j.ccell.2020.12.010
[2] Konteatis Z, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 22;64(8):4430-4449. DOI:10.1021/acs.jmedchem.0c01895

AGI-24512 Preparation Products And Raw materials

Raw materials

Preparation Products

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AGI-24512 Suppliers

China 22 United States 2 Global 24

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

AgileBioChem Co., Ltd.

Tel: 18055517827
Email: sales@agilebiochem.com
Country: China
ProdList: 1003
Advantage: 50

Shanghai Akasaka Biotechnology Co., Ltd.

Tel: 15121162054
Country: CHINA
ProdList: 635
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Email: 2261760024@qq.com
Country: China
ProdList: 4900
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9958
Advantage: 58

2201066-53-5, AGI-24512Related Search:

AGI-24512

Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(1-piperidinyl)-

Inhibitor,inhibit,DNA damage response,anticancer,methylthioadenosine phosphorylase,AGI 24512,Methionine Adenosyltransferase (MAT),PRMT5,AGI24512,AGI-24512,antiproliferative,MTAP,HCT116,S-adenosylmethionine Synthetase,MAT2A

6-(4-Hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

2201066-53-5