M-5717

Product Name: M-5717
CAS No.: 1469439-69-7
Chemical Name: M-5717
Synonyms: M-5717;DDD107498;Cabamiquine;CID 71748268;DDD107498 ，S0081;DDD107498 succinate;Cabamiquine(DDD107498;6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide;4-Quinolinecarboxamide, 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-;DDD107498,DDD 107498,DDD-498,protein,Calmodulin-dependent kinases,synthesis,antimalarial,stage,eEF2,DDD-107498,infection,Inhibitor,CaMK,multiple,Calmodulin-dependent protein kinases,DDD 498,M-5717,inhibit,M5717,Parasite
CBNumber: CB04694771
Molecular Formula: C27H31FN4O2
Formula Weight: 462.56
MOL File: 1469439-69-7.mol

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M-5717 Property

Boiling point:: 649.5±55.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥96 mg/mL in EtOH
form: solid
pka: 12.76±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0092676
Product name: DDD107498succinate
Purity: 98.72%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ApexBio Technology

Product number: A8711
Product name: DDD107498
Packaging: 5mg
Price: $438
Updated: 2021/12/16

ChemScene

Product number: CS-0092676
Product name: DDD107498succinate
Purity: 98.72%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ApexBio Technology

Product number: A8711
Product name: DDD107498
Packaging: 10mg
Price: $825
Updated: 2021/12/16

ChemScene

Product number: CS-0092676
Product name: DDD107498succinate
Purity: 98.72%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

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M-5717 Chemical Properties,Usage,Production

Uses

Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].

in vivo

Cabamiquine (p.o., a single dose) shows an ED₉₀ (90% reduction in parasitaemia) of 0.57 mg/kg in mice infected with the rodent parasiteP. berghei^[1].
Cabamiquine (p.o., 3 mg/kg) shows C_max of 80 ng/mL, T_max of 4 h, AUC of 200542 ng·min/mL, F (%) of 84%^[2].

IC 50

CaMK III; Plasmodium

References

[1] Baraga?a B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20. DOI:10.1038/nature14451
[2] Baraga?a B, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10;59(21):9672-9685.

M-5717 Preparation Products And Raw materials

Raw materials

Preparation Products

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M-5717 Suppliers

China 40 United States 4 Global 44

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
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Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
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Changzhou Yongfeng Biomedicine Co. Ltd.

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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
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1469439-69-7, M-5717Related Search:

M-5717

DDD107498 succinate

DDD107498

4-Quinolinecarboxamide, 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-

6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Cabamiquine(DDD107498

DDD107498,DDD 107498,DDD-498,protein,Calmodulin-dependent kinases,synthesis,antimalarial,stage,eEF2,DDD-107498,infection,Inhibitor,CaMK,multiple,Calmodulin-dependent protein kinases,DDD 498,M-5717,inhibit,M5717,Parasite

CID 71748268

Cabamiquine

DDD107498 ，S0081

1469439-69-7