M-5717
- Product Name
- M-5717
- CAS No.
- 1469439-69-7
- Chemical Name
- M-5717
- Synonyms
- M-5717;DDD107498;Cabamiquine;CID 71748268;DDD107498 ，S0081;DDD107498 succinate;Cabamiquine(DDD107498;6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide;4-Quinolinecarboxamide, 6-fluoro-2-[4-(4-morpholinylmethyl)phenyl]-N-[2-(1-pyrrolidinyl)ethyl]-;DDD107498,DDD 107498,DDD-498,protein,Calmodulin-dependent kinases,synthesis,antimalarial,stage,eEF2,DDD-107498,infection,Inhibitor,CaMK,multiple,Calmodulin-dependent protein kinases,DDD 498,M-5717,inhibit,M5717,Parasite
- CBNumber
- CB04694771
- Molecular Formula
- C27H31FN4O2
- Formula Weight
- 462.56
- MOL File
- 1469439-69-7.mol
M-5717 Property
- Boiling point:
- 649.5±55.0 °C(Predicted)
- Density
- 1.229±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥96 mg/mL in EtOH
- form
- solid
- pka
- 12.76±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0092676
- Product name
- DDD107498succinate
- Purity
- 98.72%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- A8711
- Product name
- DDD107498
- Packaging
- 10mg
- Price
- $825
- Updated
- 2021/12/16
- Product number
- CS-0092676
- Product name
- DDD107498succinate
- Purity
- 98.72%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0092676
- Product name
- DDD107498succinate
- Purity
- 98.72%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- A8711
- Product name
- DDD107498
- Packaging
- 5mg
- Price
- $438
- Updated
- 2021/12/16
M-5717 Chemical Properties,Usage,Production
Uses
Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].
in vivo
Cabamiquine (p.o., a single dose) shows an ED90 (90% reduction in parasitaemia) of 0.57 mg/kg in mice infected with the rodent parasiteP. berghei[1].
Cabamiquine (p.o., 3 mg/kg) shows Cmax of 80 ng/mL, Tmax of 4 h, AUC of 200542 ng·min/mL, F (%) of 84%[2].
IC 50
CaMK III; Plasmodium
References
[1] Baraga?a B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20. DOI:10.1038/nature14451
[2] Baraga?a B, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10;59(21):9672-9685.
M-5717 Preparation Products And Raw materials
Raw materials
Preparation Products
M-5717 Suppliers
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- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
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- United States
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- United States
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- United States
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- sales@medchemexpress.com
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- United States
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