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MCTR3

Product Name
MCTR3
CAS No.
1784701-63-8
Chemical Name
MCTR3
Synonyms
MCTR3;4,7,9,11,16,19-Docosahexaenoic acid, 13-[[(2R)-2-amino-2-carboxyethyl]thio]-14-hydroxy-, (4Z,7Z,9E,11E,13R,14S,16Z,19Z)-
CBNumber
CB04718633
Molecular Formula
C25H37NO5S
Formula Weight
463.63
MOL File
1784701-63-8.mol
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MCTR3 Property

Boiling point:
693.1±55.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
EtOH/H2O (95:5): 2 mg/ml; DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
pka
2.05±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19067
Product name
MCTR3
Packaging
50μg
Price
$653
Updated
2024/03/01
Cayman Chemical
Product number
19067
Product name
MCTR3
Packaging
100μg
Price
$943
Updated
2024/03/01
Cayman Chemical
Product number
19067
Product name
MCTR3
Packaging
10μg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
19067
Product name
MCTR3
Packaging
25μg
Price
$344
Updated
2024/03/01
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MCTR3 Chemical Properties,Usage,Production

Description

Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages.1,2 DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase.3 MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1.2 Pretreatment with MCTR3 prior to E. coli administration in mice reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR3 selectively reduces the amount of the eicosanoids PGD2 , PGE2 , PGF2α , and TXB2 in the exudate.

References

1. Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology Nature 510(7503),92-101(2014).
2. Dalli, K.J., Sanger, J.M., Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3 PLoS One 11(2),e0149319(2016).
3. Dalli, J., Vlasakov, I., Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. USA 113(43),12232-12237(2016).

MCTR3 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCTR3 Suppliers

China 7 United States 2 Global 9
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7978
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19699
Advantage
58

1784701-63-8, MCTR3Related Search:


  • MCTR3
  • 4,7,9,11,16,19-Docosahexaenoic acid, 13-[[(2R)-2-amino-2-carboxyethyl]thio]-14-hydroxy-, (4Z,7Z,9E,11E,13R,14S,16Z,19Z)-
  • 1784701-63-8