Calcium gluconate Property

Melting point:

195°C

alpha 

10.2 º (c=1, H2O 22 ºC)

Boiling point:

400℃[at 101 325 Pa]

Density 

1.677[at 20℃]

vapor pressure 

0.004Pa at 20℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Sparingly soluble in water, freely soluble in boiling water.

form 

Crystals or Crystalline Powder

color 

White

PH

pH;6.0～8.0

Odor

at 100.00?%. odorless

Water Solubility 

3.3 g/100mL

Hydrolytic Sensitivity

0: forms stable aqueous solutions

Merck 

14,1669

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

KYUVBRZSDFBLTH-OSQBQZLYSA-M

LogP

-5.31 at 20℃

CAS DataBase Reference

299-28-5(CAS DataBase Reference)

EPA Substance Registry System

D-Gluconic acid, calcium salt (2:1) (299-28-5)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

1

RTECS 

EW2100000

TSCA 

No

HS Code 

29181600

Hazardous Substances Data

299-28-5(Hazardous Substances Data)

Toxicity

dog,LDLo,intravenous,1987mg/kg (1987mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Calcium gluconate Chemical Properties,Usage,Production

Description

Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses.

References

http://www.drugbank.ca/drugs/DB11126 https://en.wikipedia.org/wiki/Calcium_gluconate

Chemical Properties

white crystalline powder or granules

Uses

analgesic, antipyretic

Uses

In sewage purification; in coffee powders to prevent caking.

Uses

Calcium Gluconate is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and sta- bilizer. at room temperature the anhydrous form has a solubility of approximately 1 g in 30 ml of water, which improves in boiling water to approximately 1 g in 5 ml of water. it also exists as calcium gluconate (monohydrate). it is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, pud- dings, and dairy product analogs. it functions as a coagulation aid in milk and instant pudding powders and as a means of masking the bitter aftertaste of some artificial sweeteners.

Uses

Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium.

Definition

ChEBI: Calcium gluconate is the calcium salt of D-gluconic acid. It has a role as a nutraceutical. It contains a D-gluconate.

brand name

Calglucon (Novartis).

Flammability and Explosibility

Non flammable

Industrial uses

calcium gluconate [Ca(C₆H₁₁O₇)₂] is used as a food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept in mind that the plasma Ca²⁺ level and any changes to the electrocardiogram (ECG) have to be carefully monitored.

Clinical Use

Hypocalcaemia

Safety Profile

Moderately toxic by subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects in infants by intramuscular route: dermatitis and fever. When heated to decomposition it emits acrid smoke and fumes. See also CALCIUM COMPOUNDS.

Veterinary Drugs and Treatments

Calcium salts are used for the prevention or treatment of hypocalcemic conditions.

Drug interactions

Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron, ciprofloxacin.

Metabolism

Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails.

Purification Methods

Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]