XESTOSPONGIN C
- Product Name
- XESTOSPONGIN C
- CAS No.
- 88903-69-9
- Chemical Name
- XESTOSPONGIN C
- Synonyms
- XEC;XESTOSPONGIN;ARGUSPONGINE E;XESTOSPONGIN C;(-)-Xestospongin C;PQYOPBRFUUEHRC-HCKQMYSWSA-N;Xestospongin C((-)-Xestospongin C);Xestospongin C, IP3 receptor antagonist;Xestospongin C 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate;(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
- CBNumber
- CB0479020
- Molecular Formula
- C28H50N2O2
- Formula Weight
- 446.71
- MOL File
- 88903-69-9.mol
XESTOSPONGIN C Property
- Melting point:
- 146-147 °C(Solv: acetone (67-64-1))
- Boiling point:
- 564.7±35.0 °C(Predicted)
- Density
- 1.05±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- film
- pka
- 7.73±0.20(Predicted)
- color
- off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- X2628
- Product name
- Xestospongin C
- Purity
- film
- Packaging
- 10μg
- Price
- $463
- Updated
- 2024/03/01
- Product number
- X2628
- Product name
- Xestospongin C
- Purity
- film
- Packaging
- 50μg
- Price
- $1670
- Updated
- 2024/03/01
- Product number
- 64950
- Product name
- Xestospongin C
- Purity
- ≥90%
- Packaging
- 10μg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 64950
- Product name
- Xestospongin C
- Purity
- ≥90%
- Packaging
- 50μg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 64950
- Product name
- Xestospongin C
- Purity
- ≥90%
- Packaging
- 100μg
- Price
- $629
- Updated
- 2024/03/01
XESTOSPONGIN C Chemical Properties,Usage,Production
Description
Xestospongin C (88903-69-9) is a potent and reversible inhibitor of IP3-mediated Ca2+?release, IC50?= 358 nM.1?Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+?and K+?currents at a concentration range similar to that at which it inhibits the IP3 receptor. Xestospongin C is a useful tool for probing the involvement of IP3 receptors in cellular signaling.3?Cell permeable.
Uses
Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 μM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.
Uses
Xestospongin C is a potent, membrane-permeable IP3 receptor blocker.
Definition
ChEBI: An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
General Description
Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.
Biochem/physiol Actions
Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
storage
Store at -20°C
References
1) Wilcox?et al. (1998),?New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor;? Trends Pharmacol. Sci.,?19?467 2) Ozaki?et al. (2002),?Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle;? Br. J. Pharmacol.,?137?1207 3) Kandasamy?et al. (2013),?Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels;? PLoS One,?8?e63465
XESTOSPONGIN C Preparation Products And Raw materials
Raw materials
Preparation Products
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