DL-THIORPHAN
- Product Name
- DL-THIORPHAN
- CAS No.
- 76721-89-6
- Chemical Name
- DL-THIORPHAN
- Synonyms
- C01619;THIORPHAN;Thiorphan-d5;DL-THIORPHAN;THIORPHAN (DL);DL-THIORPHAN USP/EP/BP;Bisoprolol FuMarate IMpurity-Q;(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY;(2-benzyl-3-mercaptopropanoyl)glycine;DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE
- CBNumber
- CB0479626
- Molecular Formula
- C12H15NO3S
- Formula Weight
- 253.32
- MOL File
- 76721-89-6.mol
DL-THIORPHAN Property
- Melting point:
- 138-140 °C
- Boiling point:
- 524.0±50.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- RTECS
- MC0596440
- storage temp.
- -15°C
- solubility
- ethanol: 50 mg/mL, clear, colorless
- form
- White solid
- pka
- 3.48±0.10(Predicted)
- color
- White to Off-White
- BRN
- 4872101
- CAS DataBase Reference
- 76721-89-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T6031
- Product name
- DL-Thiorphan
- Purity
- ≥98% (TLC)
- Packaging
- 5mg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 598510
- Product name
- DL-Thiorphan
- Packaging
- 10mg
- Price
- $378
- Updated
- 2023/01/07
- Product number
- J62557
- Product name
- DL-Thiorphan
- Packaging
- 25mg
- Price
- $459.65
- Updated
- 2024/03/01
- Product number
- 15600
- Product name
- Thiorphan
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15600
- Product name
- Thiorphan
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
DL-THIORPHAN Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
An Enkephalinase inhibitor
Uses
Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.
Uses
DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.
Uses
The active metabolite
Definition
ChEBI: Thiorphan is a N-acyl-amino acid.
General Description
A thiol-containing amido-acid that selectively binds to the active site zinc of neprilysin (also known as neutral endopeptidase and NEP) and inhibits its activity (IC50 = 2.1 nM). Inhibits the β-amyloid (Aβ) degrading activity of neprilysin in vivo, but does not affect the secretion of either Aβ peptide or amyloid precursor protein (APP). Also shown to inhibit other neprilysin-related family members, such as mouse NL1 (IC50 = 47 nM) and the neprilysin homolog from Ascaris suum (IC50 = 22 μM). Inhibits the activity of angiotensin-converting enzyme (ACE) (IC50 = 140 nM), but has no effect on the activity of endothelin-converting enzyme (ECE).
Biochem/physiol Actions
Primary TargetNEP activity
DL-THIORPHAN Preparation Products And Raw materials
Raw materials
Preparation Products
DL-THIORPHAN Suppliers
- Tel
- 027-19050701 13545374703
- cbbspring@163.com
- Country
- China
- ProdList
- 324
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 010-52878169 15701683040
- sales@bjcomparison.com
- Country
- China
- ProdList
- 4689
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17981
- Advantage
- 56
- Tel
- 021-00000000 19916721580
- Fax
- QQ:3154870176
- info@mashilabs.com
- Country
- China
- ProdList
- 4115
- Advantage
- 58
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- +86-21-61263310; 13764994101 13764994101
- Fax
- 021-61263399
- fisherwang@glschina.com
- Country
- China
- ProdList
- 8458
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 0510-83583050 13771062561
- Fax
- 0510-83583039
- willsun@peptide-search.com
- Country
- China
- ProdList
- 6716
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6018
- Advantage
- 55
- Tel
- 0755-28967200 13631290199
- Fax
- 0755-28967200
- wxf@sungening.com
- Country
- China
- ProdList
- 9507
- Advantage
- 60
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 010-010-62971590 18548936886
- Fax
- 010-62340519
- 3462612863@qq.com
- Country
- China
- ProdList
- 6912
- Advantage
- 58
- Tel
- 0411-39042497
- Fax
- 0411-39042693
- sales@alphabiopharm.com
- Country
- China
- ProdList
- 1951
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 0551-66336380 18956014586
- Fax
- 055166336380
- 983438788@qq.com
- Country
- China
- ProdList
- 2077
- Advantage
- 58
- Tel
- 021-61263370 18901917034
- xingli@glbiochem.com
- Country
- China
- ProdList
- 5637
- Advantage
- 58
- Tel
- 021-61263377 15023907684
- Fax
- 021-61263399
- 15800684150@163.com
- Country
- China
- ProdList
- 8131
- Advantage
- 58
- Tel
- +86-021-61263370 +86-18901917034
- Country
- CHINA
- ProdList
- 3904
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12382
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19915
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652,+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 28812
- Advantage
- 58
- Tel
- +86-021-61263370 +8615301650015
- wuqiuyan@glschina.com
- Country
- China
- ProdList
- 2975
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 17825480238
- Fax
- QQ 3008233717
- 3008233717@qq.com
- Country
- China
- ProdList
- 9844
- Advantage
- 12
- Tel
- 021-61263389 13524856427
- Fax
- WeChat630417570
- Joetang@glschina.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- 021-61263375 18168859245
- Country
- China
- ProdList
- 5958
- Advantage
- 58
- Tel
- 86-13657291602
- Fax
- 027-59338440
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 22968
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14253
- Advantage
- 58
- Tel
- 15061806929
- linda-fu@mimotopes.cn
- Country
- China
- ProdList
- 5854
- Advantage
- 58
- Tel
- 18096409024
- sales02@foreversyn.com
- Country
- China
- ProdList
- 1947
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 18217475093
- 1615396342@qq.com
- Country
- China
- ProdList
- 4309
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7844
- Advantage
- 58
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Country
- China
- ProdList
- 8128
- Advantage
- 58
- Tel
- 0755-0755-0755-83725350 13380397412
- Fax
- 0755-28094224
- 3001280422@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44941
- Advantage
- 58
- Tel
- 020-36607679 13502246435
- sales@dmstandards.com
- Country
- China
- ProdList
- 10951
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44490
- Advantage
- 58