ChemicalBook > CAS DataBase List > (±)-BAY-1251152

(±)-BAY-1251152

Product Name: (±)-BAY-1251152
CAS No.: 1610358-53-6
Chemical Name: (±)-BAY-1251152
Synonyms: bay15251152;(±)-Enitociclib;(±)-Enitociclib, 10 mM in DMSO;(±)-Enitociclib,Cyclin dependent kinase,(±)Enitociclib,(±)-VIP152,inhibit,(±) Enitociclib,CDK,Inhibitor;2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-;((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone
CBNumber: CB04796628
Molecular Formula: C19H18F2N4O2S
Formula Weight: 404.43
MOL File: 1610358-53-6.mol

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(±)-BAY-1251152 Property

Boiling point:: 494.2±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);123.63(Max Conc. mM)
form: A solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028326
Product name: (±)-BAY-1251152
Purity: 99.87%
Packaging: 2mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0028326
Product name: (±)-BAY-1251152
Purity: 99.87%
Packaging: 5mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0028326
Product name: (±)-BAY-1251152
Purity: 99.87%
Packaging: 10mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0028326
Product name: (±)-BAY-1251152
Purity: 99.87%
Packaging: 50mg
Price: $890
Updated: 2021/12/16

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(±)-BAY-1251152 Chemical Properties,Usage,Production

Uses

(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY-1251152 can be used in the study of acute myelogenous leukemia and double-hit diffuse large B-cell lymphoma[1][2].

References

[1] Byrne M, et al. Phase I study of the PTEFb inhibitor BAY 1251152 in patients with acute myelogenous leukemia. Blood, 2018, 132: 4055.
[2] Lücking U, et al. Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer. J Med Chem. 2021 Aug 12;64(15):11651-11674. DOI:10.1021/acs.jmedchem.1c01000

(±)-BAY-1251152 Preparation Products And Raw materials

Raw materials

Preparation Products

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1610358-53-6, (±)-BAY-1251152Related Search:

bay15251152

2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-

((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

(±)-Enitociclib

(±)-Enitociclib,Cyclin dependent kinase,(±)Enitociclib,(±)-VIP152,inhibit,(±) Enitociclib,CDK,Inhibitor

(±)-Enitociclib, 10 mM in DMSO

1610358-53-6

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