E-7386

Product Name: E-7386
CAS No.: 1799824-08-0
Chemical Name: E-7386
Synonyms: E-7386, 10 mM in DMSO;E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor;(6S,9aS)-2-Allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide;2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)-
CBNumber: CB04796648
Molecular Formula: C39H48FN9O4
Formula Weight: 725.85
MOL File: 1799824-08-0.mol

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E-7386 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);172.21(Max Conc. mM)
form: Solid
pka: 8.92±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E102405
Product name: E-7386
Packaging: 1mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 5mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 10mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 50mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 1mg
Price: $110
Updated: 2021/12/16

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E-7386 Chemical Properties,Usage,Production

Uses

E-7386, is an CBP/beta-catenin modulator that is shown to be orally active. E-7386, has shown high antitumor activity in Wnt1 model.

in vivo

E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group^[1].

E-7386 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-7386 Suppliers

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1799824-08-0, E-7386Related Search:

2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)-

E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor

(6S,9aS)-2-Allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide

E-7386, 10 mM in DMSO

1799824-08-0

C39H48FN9O4