Nemorexant

Product Name: Nemorexant
CAS No.: 1505484-82-1
Chemical Name: Nemorexant
Synonyms: Daridorexant;Nemorexant;Daridorexant，Nemorexant;emorexant, Daridorexant;(S)-[2-(6-Chloro-7-methyl-2-benzimidazolyl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;Methanone, [(2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]-
CBNumber: CB04796673
Molecular Formula: C23H23ClN6O2
Formula Weight: 450.92
MOL File: 1505484-82-1.mol

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Nemorexant Property

Boiling point:: 747.6±70.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 250 mg/mL (554.42 mM)
pka: 10.47±0.30(Predicted)
InChIKey: NBGABHGMJVIVBW-QHCPKHFHSA-N
SMILES: C(N1CCC[C@]1(C1NC2=C(C)C(Cl)=CC=C2N=1)C)(C1=CC(OC)=CC=C1N1N=CC=N1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039396
Product name: Nemorexant
Purity: 99.56%
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0039396
Product name: Nemorexant
Purity: 99.56%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0039396
Product name: Nemorexant
Purity: 99.56%
Packaging: 10mg
Price: $530
Updated: 2021/12/16

ChemScene

Product number: CS-0039396
Product name: Nemorexant
Purity: 99.56%
Packaging: 25mg
Price: $1050
Updated: 2021/12/16

ChemScene

Product number: CS-0039396
Product name: Nemorexant
Purity: 99.56%
Packaging: 50mg
Price: $1540
Updated: 2021/12/16

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Nemorexant Chemical Properties,Usage,Production

Uses

[(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone,

Synthesis

Actelion has applied for a patented synthesis of daridorexant. Starting from the raw amino acid 13.1, it was protected by N-Boc with a yield of 80% (Figure 3.4). Next, amide 13.4 was obtained by HATU-mediated amide coupling with o-phenylenediamine 13.3, which was used directly as a crude product in subsequent reactions. Condensation in hot acetic acid gave benzimidazole 13.5 with a yield of 81%. Removal of the N-Boc protecting group with anhydrous dioxane-hydrochloric acid gave pyrrolidine 13.6; however, the salt equivalent and yield of this step were not reported. Carboxylic acid 13.7 was prepared from the corresponding aryl iodide and 1,2,3-triazole by copper-mediated C-N bond coupling, which finally formed an amide bond with pyrrolidine 13.6 to generate daridorexant (13).

Nemorexant Preparation Products And Raw materials

Raw materials

Preparation Products

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Nemorexant Suppliers

China 72 India 2 United States 2 Global 76

Beijing Jingzi Pharmaceutical Technology Co., Ltd.

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Wuhan HSN Pharmaresearch CO., LTD.

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Shanghai Lollane Biological Technology Co.,Ltd.

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View Lastest Price from Nemorexant manufacturers

Moxin Chemicals

Product: Daridorexant 1505484-82-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-06-27

1505484-82-1, NemorexantRelated Search:

Nemorexant

Methanone, [(2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]-

Daridorexant

Daridorexant，Nemorexant

(S)-[2-(6-Chloro-7-methyl-2-benzimidazolyl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

emorexant, Daridorexant

(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

1505484-82-1

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