Nemorexant
- Product Name
- Nemorexant
- CAS No.
- 1505484-82-1
- Chemical Name
- Nemorexant
- Synonyms
- Daridorexant;Nemorexant;Daridorexant，Nemorexant;emorexant, Daridorexant;(S)-[2-(6-Chloro-7-methyl-2-benzimidazolyl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;Methanone, [(2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]-
- CBNumber
- CB04796673
- Molecular Formula
- C23H23ClN6O2
- Formula Weight
- 450.92
- MOL File
- 1505484-82-1.mol
Nemorexant Property
- Boiling point:
- 747.6±70.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 250 mg/mL (554.42 mM)
- pka
- 10.47±0.30(Predicted)
- InChIKey
- NBGABHGMJVIVBW-QHCPKHFHSA-N
- SMILES
- C(N1CCC[C@]1(C1NC2=C(C)C(Cl)=CC=C2N=1)C)(C1=CC(OC)=CC=C1N1N=CC=N1)=O
N-Bromosuccinimide Price
- Product number
- CS-0039396
- Product name
- Nemorexant
- Purity
- 99.56%
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0039396
- Product name
- Nemorexant
- Purity
- 99.56%
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0039396
- Product name
- Nemorexant
- Purity
- 99.56%
- Packaging
- 10mg
- Price
- $530
- Updated
- 2021/12/16
- Product number
- CS-0039396
- Product name
- Nemorexant
- Purity
- 99.56%
- Packaging
- 25mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CS-0039396
- Product name
- Nemorexant
- Purity
- 99.56%
- Packaging
- 50mg
- Price
- $1540
- Updated
- 2021/12/16
Nemorexant Chemical Properties,Usage,Production
Uses
[(2S)-2-(6-Chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone,
Synthesis
Actelion has applied for a patented synthesis of daridorexant. Starting from the raw amino acid 13.1, it was protected by N-Boc with a yield of 80% (Figure 3.4). Next, amide 13.4 was obtained by HATU-mediated amide coupling with o-phenylenediamine 13.3, which was used directly as a crude product in subsequent reactions. Condensation in hot acetic acid gave benzimidazole 13.5 with a yield of 81%. Removal of the N-Boc protecting group with anhydrous dioxane-hydrochloric acid gave pyrrolidine 13.6; however, the salt equivalent and yield of this step were not reported. Carboxylic acid 13.7 was prepared from the corresponding aryl iodide and 1,2,3-triazole by copper-mediated C-N bond coupling, which finally formed an amide bond with pyrrolidine 13.6 to generate daridorexant (13).
Nemorexant Preparation Products And Raw materials
Raw materials
Preparation Products
Nemorexant Suppliers
View Lastest Price from Nemorexant manufacturers
- Product
- Daridorexant 1505484-82-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 99%+ HPLC
- Supply Ability
- 1000
- Release date
- 2025-06-27