ChemicalBook > CAS DataBase List > CH7057288

CH7057288

Product Name
CH7057288
CAS No.
2095616-82-1
Chemical Name
CH7057288
Synonyms
CH7057288;CH7057288, 10 mM in DMSO;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
CBNumber
CB04797034
Molecular Formula
C32H31N3O5S
Formula Weight
569.67
MOL File
2095616-82-1.mol
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CH7057288 Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM)
form 
Solid
pka
6.89±0.40(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
50mg
Price
$1750
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
100mg
Price
$2750
Updated
2021/12/16
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CH7057288 Chemical Properties,Usage,Production

Uses

CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.

in vitro

In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TrkB
(Cell-free assay)
TargetValue
TrkA
(Cell-free assay)		 1.1 nM
TrkC
(Cell-free assay)		 5.1 nM
7.8 nM

IC 50

TRK

References

[1] Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.

CH7057288 Preparation Products And Raw materials

Raw materials

Preparation Products

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CH7057288 Suppliers

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2095616-82-1, CH7057288Related Search:


  • CH7057288
  • 4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
  • Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288
  • CH7057288, 10 mM in DMSO
  • 2095616-82-1