ChemicalBook > CAS DataBase List > UPGL00004
UPGL00004
- Product Name
- UPGL00004
- CAS No.
- 1890169-95-5
- Chemical Name
- UPGL00004
- Synonyms
- UPGL00004;UPGL00004,UPGL-00004;2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide;Benzeneacetamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-
- CBNumber
- CB04800860
- Molecular Formula
- C25H26N8O2S2
- Formula Weight
- 534.66
- MOL File
- 1890169-95-5.mol
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UPGL00004 Property
- Density
- 1.460±0.06 g/cm3(Predicted)
- pka
- 9.23±0.50(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0068007
- Product name
- UPGL00004
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0068007
- Product name
- UPGL00004
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $1200
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573368
- Product name
- UPGL00004
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1208.7
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573368
- Product name
- UPGL00004
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2395.3
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573368
- Product name
- UPGL00004
- Purity
- >98%
- Packaging
- 1g
- Price
- $4766.8
- Updated
- 2021/12/16
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UPGL00004 Chemical Properties,Usage,Production
Biological Activity
UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.
in vitro
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.
in vivo
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.
target
Target | Value |
glutaminase C (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM
UPGL00004 Preparation Products And Raw materials
Raw materials
Preparation Products
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UPGL00004 Suppliers
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