ChemicalBook > CAS DataBase List > Alloc-Val-Ala-OH

Alloc-Val-Ala-OH

Product Name
Alloc-Val-Ala-OH
CAS No.
330970-70-2
Chemical Name
Alloc-Val-Ala-OH
Synonyms
Alloc-Val-Ala-OH;((Allyloxy)carbonyl)-L-valyl-L-alanine;L-Alanine, N-[(2-propen-1-yloxy)carbonyl]-L-valyl-;(S)-2-((S)-2-(Allyloxycarbonylamino)-3-methylbutanamido)propanoic acid;(2S)-2-[(2S)-3-methyl-2-{[(prop-2-en-1-yloxy)carbonyl]amino}butanamido]propanoic acid
CBNumber
CB04804398
Molecular Formula
C12H20N2O5
Formula Weight
272.3
MOL File
330970-70-2.mol
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Alloc-Val-Ala-OH Property

Boiling point:
498.3±40.0 °C(Predicted)
Density 
1.155±0.06 g/cm3(Predicted)
pka
3.49±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A549735
Product name
N-Alloc-L-valyl-L-alanine
Packaging
500mg
Price
$305
Updated
2021/12/16
TRC
Product number
A549735
Product name
N-Alloc-L-valyl-L-alanine
Packaging
1g
Price
$550
Updated
2021/12/16
TRC
Product number
A549735
Product name
N-Alloc-L-valyl-L-alanine
Packaging
5g
Price
$2310
Updated
2021/12/16
TRC
Product number
A549735
Product name
N-Alloc-L-valyl-L-alanine
Packaging
10g
Price
$4180
Updated
2021/12/16
Matrix Scientific
Product number
179881
Product name
L-Alanine
Purity
N-[(2-propen-1-yloxy)carbonyl]-L-valyl-95%
Packaging
1g
Price
$1486
Updated
2021/12/16
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Alloc-Val-Ala-OH Chemical Properties,Usage,Production

Description

Alloc-Val-Ala-OH is a peptide linker with a terminal carboxylic acid group and an Alloc protecting group. The peptide chain can act as a cleavable linker in drug design, such as in antibody drug conjugates (ADC). The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Alloc group is stable to treatment with piperidine and TFA, and can be removed in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3. This allows the allyl system to work orthogonality with the most common protecting groups.

Uses

N-Alloc-L-valyl-L-alanine is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload.

Alloc-Val-Ala-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Alloc-Val-Ala-OH Suppliers

Shanghai GL Peptide Ltd.
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Shanghai SuperLan Chemcial Technique Centre
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Wuxi Asia Peptide Biotechnology Limited Company
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Nextpeptide Inc
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View Lastest Price from Alloc-Val-Ala-OH manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Alloc-Val-Ala-OH 330970-70-2
Price
US $0.00/g
Min. Order
25g
Purity
>95.00%
Supply Ability
25g
Release date
2024-03-29

330970-70-2, Alloc-Val-Ala-OHRelated Search:


  • ((Allyloxy)carbonyl)-L-valyl-L-alanine
  • Alloc-Val-Ala-OH
  • (2S)-2-[(2S)-3-methyl-2-{[(prop-2-en-1-yloxy)carbonyl]amino}butanamido]propanoic acid
  • L-Alanine, N-[(2-propen-1-yloxy)carbonyl]-L-valyl-
  • (S)-2-((S)-2-(Allyloxycarbonylamino)-3-methylbutanamido)propanoic acid
  • 330970-70-2