ChemicalBook > CAS DataBase List > CA-5f

CA-5f

Product Name
CA-5f
CAS No.
1370032-19-1
Chemical Name
CA-5f
Synonyms
CA-5f;CA-5F;CA 5F;CA5F;1370032-19-1;-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f;(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one;(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one;4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
CBNumber
CB04808619
Molecular Formula
C24H24N2O3
Formula Weight
388.46
MOL File
1370032-19-1.mol
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CA-5f Property

Boiling point:
639.7±55.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble)
pka
16.06±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573239
Product name
CA-5f
Purity
>98%
Packaging
100mg
Price
$838.1
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573182
Product name
CA-5f
Purity
>98%
Packaging
100mg
Price
$986
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573239
Product name
CA-5f
Purity
>98%
Packaging
250mg
Price
$1431.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573182
Product name
CA-5f
Purity
>98%
Packaging
250mg
Price
$1802
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573239
Product name
CA-5f
Purity
>98%
Packaging
1g
Price
$2839
Updated
2021/12/16
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CA-5f Chemical Properties,Usage,Production

Biological Activity

CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity.

in vivo

CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.

< td class="col2"> Nude mice bearing A549 lung cancer cells
Animal Model:
Dosage: 40 mg /kg
Administration: Injected via caudal vein, every 2 days for up to 30 days < /td>
Result: Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice .

target

Macroautophagy/autophagy

CA-5f Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-5f Suppliers

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1370032-19-1, CA-5fRelated Search:


  • CA-5f
  • CA-5F;CA 5F;CA5F;1370032-19-1
  • 4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
  • -5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
  • (E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one
  • CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f
  • (3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
  • 1370032-19-1
  • API