JAK3-IN-6
- Product Name
- JAK3-IN-6
- CAS No.
- 1443235-95-7
- Chemical Name
- JAK3-IN-6
- Synonyms
- JAK3-IN-2;JAK3-IN-6;JAK3 inhibitor 6;JAK3-IN-6 (Compound 2);SelectiveJAK3inhibitor1;JAK3-IN-6, 10 mM in DMSO;JAK3-IN-2 (JAK3 inhibitor 2);inhibit,JAK3 IN 6,JAK,Inhibitor,JAK3IN6,JAK-3-IN-6,Janus kinase;Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- CBNumber
- CB04813521
- Molecular Formula
- C19H18N4O3
- Formula Weight
- 350.37
- MOL File
- 1443235-95-7.mol
JAK3-IN-6 Property
- Density
- 1.302±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 260 mg/mL (742.07 mM)
- pka
- 10.26±0.50(Predicted)
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- CS-0022365
- Product name
- JAK3-IN-6
- Purity
- 98.07%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0022365
- Product name
- JAK3-IN-6
- Purity
- 98.07%
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CS-0022365
- Product name
- JAK3-IN-6
- Purity
- 98.07%
- Packaging
- 50mg
- Price
- $465
- Updated
- 2021/12/16
- Product number
- DC21158
- Product name
- JAK3-IN-2
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- DC21158
- Product name
- JAK3-IN-2
- Purity
- >98%
- Packaging
- 1g
- Price
- $2200
- Updated
- 2021/12/16
JAK3-IN-6 Chemical Properties,Usage,Production
Uses
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM.
Biological Activity
JAK3-IN-6 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM and 740 nM for JAK3, JAK1 and JAK2, respectively. It is more selective for JAK3 than BMX, EGFR, ITK and BTK.
in vitro
JAK3-IN-6 is a potent JAK3 inhibitor with IC50 of 0.15 nM, with 4300-fold selectivity for JAK3 over JAK1 in enzymatic activity assays, erythropoietin and 67-fold and 140-fold higher selectivity for granulocyte-macrophage colony-stimulating factor.
in vivo
JAK3-IN-6 completely inhibits the progression of inflammatory responses.
target
| Target | Value |
| JAK3 (Cell-free assay) | 0.07 nM(Ki) |
| JAK1 (Cell-free assay) | 320 nM(Ki) |
| JAK2 (Cell-free assay) | 740 nM(Ki) |
IC 50
JAK3: 0.15 nM (IC50)
References
[1] ARYL SULFONOHYDRAZIDES. WO2017027400A1.
[2] Elwood F, et al. Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor. J Pharmacol Exp Ther. 2017 May;361(2):229-244. DOI:10.1124/jpet.116.239723
JAK3-IN-6 Preparation Products And Raw materials
Raw materials
Preparation Products
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