JAK3-IN-6

ChemicalBook > CAS DataBase List > JAK3-IN-6

Product Name: JAK3-IN-6
CAS No.: 1443235-95-7
Chemical Name: JAK3-IN-6
Synonyms: JAK3-IN-2;JAK3-IN-6;JAK3 inhibitor 6;JAK3-IN-6 (Compound 2);SelectiveJAK3inhibitor1;JAK3-IN-2 (JAK3 inhibitor 2);inhibit,JAK3 IN 6,JAK,Inhibitor,JAK3IN6,JAK-3-IN-6,Janus kinase;Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-, ethyl ester
CBNumber: CB04813521
Molecular Formula: C19H18N4O3
Formula Weight: 350.37
MOL File: 1443235-95-7.mol

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JAK3-IN-6 Property

Density: 1.302±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 260 mg/mL (742.07 mM)
pka: 10.26±0.50(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0022365
Product name: JAK3-IN-6
Purity: 98.07%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0022365
Product name: JAK3-IN-6
Purity: 98.07%
Packaging: 10mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0022365
Product name: JAK3-IN-6
Purity: 98.07%
Packaging: 50mg
Price: $465
Updated: 2021/12/16

DC Chemicals

Product number: DC21158
Product name: JAK3-IN-2
Purity: >98%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

DC Chemicals

Product number: DC21158
Product name: JAK3-IN-2
Purity: >98%
Packaging: 1g
Price: $2200
Updated: 2021/12/16

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JAK3-IN-6 Chemical Properties,Usage,Production

Biological Activity

JAK3-IN-6 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM and 740 nM for JAK3, JAK1 and JAK2, respectively. It is more selective for JAK3 than BMX, EGFR, ITK and BTK.

in vitro

JAK3-IN-6 is a potent JAK3 inhibitor with IC50 of 0.15 nM, with 4300-fold selectivity for JAK3 over JAK1 in enzymatic activity assays, erythropoietin and 67-fold and 140-fold higher selectivity for granulocyte-macrophage colony-stimulating factor.

in vivo

JAK3-IN-6 completely inhibits the progression of inflammatory responses.

target

Target	Value
JAK3 (Cell-free assay)	0.07 nM(Ki)
JAK1 (Cell-free assay)	320 nM(Ki)
JAK2 (Cell-free assay)	740 nM(Ki)

JAK3-IN-6 Preparation Products And Raw materials

Raw materials

Preparation Products

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1443235-95-7, JAK3-IN-6Related Search:

JAK-IN-5 2091134-35-7

JAK3-IN-6

SelectiveJAK3inhibitor1

ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

JAK3-IN-2 (JAK3 inhibitor 2)

JAK3-IN-2

JAK3 inhibitor 6

7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-, ethyl ester

JAK3-IN-6 (Compound 2)

inhibit,JAK3 IN 6,JAK,Inhibitor,JAK3IN6,JAK-3-IN-6,Janus kinase

Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

1443235-95-7