NAB 2

Product Name: NAB 2
CAS No.: 1504588-00-4
Chemical Name: NAB 2
Synonyms: NAB 2;alphaSYN-IN-NAB2;NAB2 >=98% (HPLC);alphaSYN inhibitor-NAB2;alphaSYN inhibitor NAB2;alphaSYN IN NAB2,alphaSYN-IN-NAB-2;Nedd4/Rsp5 Signaling Inducer, NAB2;N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-;N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-1,3-benzodiazole-5-carboxamide
CBNumber: CB04814917
Molecular Formula: C23H20ClN3O
Formula Weight: 389.88
MOL File: 1504588-00-4.mol

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NAB 2 Property

Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL
form: A crystalline solid
pka: 13.04±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26145
Product name: NAB 2
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 26145
Product name: NAB 2
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 26145
Product name: NAB 2
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Tocris

Product number: 5131
Product name: NAB2
Purity: ≥98%(HPLC)
Packaging: 50
Price: $861
Updated: 2021/12/16

Tocris

Product number: 5131
Product name: NAB2
Purity: ≥98%(HPLC)
Packaging: 10
Price: $206
Updated: 2021/12/16

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NAB 2 Chemical Properties,Usage,Production

Description

alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..

Uses

NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease[1][2][3].

Definition

ChEBI: N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide is an aromatic amide obtained by the formal condensation of the carboxy group of 1-(2,5-dimethylphenyl)benzimidazole-5-carboxylic acid with the amino group of 2-chlorobenzylamine. It is a member of benzimidazoles, an aromatic amide, a monocarboxylic acid amide and a member of monochlorobenzenes.

IC 50

α-synuclein

storage

Store at +4°C

References

[1] Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983. DOI:10.1126/science.1245321
[2] Hatstat AK, et al. Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity. RSC Chem Biol. 2021 Nov 9;3(1):96-111. DOI:10.1039/d1cb00103e

NAB 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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NAB 2 Suppliers

China 36 United Kingdom 1 United States 4 USA 1 Global 42

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

Beijing Biocreative Technology Co., Ltd.

Tel: 15522676233
Email: 3007606172@qq.com
Country: China
ProdList: 1248
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

1504588-00-4, NAB 2Related Search:

NAB 2

N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide

NAB2 >=98% (HPLC)

alphaSYN-IN-NAB2

N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-1,3-benzodiazole-5-carboxamide

alphaSYN inhibitor NAB2

alphaSYN inhibitor-NAB2

alphaSYN IN NAB2,alphaSYN-IN-NAB-2

1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-

Nedd4/Rsp5 Signaling Inducer, NAB2

1504588-00-4