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VITAMIN K1

Product Name
VITAMIN K1
CAS No.
12001-79-5
Chemical Name
VITAMIN K1
Synonyms
VITAMIN K;vitamine K;6E)-1;C01628;Kanavit;Synkavite;7-Diphenyl-4;VITAMIN K1 USP23;6-heptadien-3-one;Vitamin K substances
CBNumber
CB0482554
Molecular Formula
C31H46O2
Formula Weight
450.7
MOL File
12001-79-5.mol
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VITAMIN K1 Property

Melting point:
−20 °C(lit.)
Density 
0.984 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.527(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
viscous liquid
LogP
10.305 (est)
CAS DataBase Reference
12001-79-5
IARC
3 (Vol. 76) 2000
EPA Substance Registry System
Vitamin K (12001-79-5)
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Safety

WGK Germany 
2
RTECS 
QJ5800000
1-8-10
Toxicity
mouse,LD50,subcutaneous,700mg/kg (700mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
VIT0000058
Product name
VITAMIN K
Purity
95.00%
Packaging
5MG
Price
$501.24
Updated
2021/12/16
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VITAMIN K1 Chemical Properties,Usage,Production

Definition

ChEBI: 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione is a member of 1,4-naphthoquinones.

Biological Functions

Both vitamins K3 and K4 may produce hyperbilirubinemia and kernicterus in neonates as well as hemolysis in neonates and glucose-6-phosphate–deficient patients. In fact, the only advantage of vitamins K3 and K4 over vitamin K1 is that whereas absorption of vitamin K1 requires the presence of bile, absorption of vitamins K3 and K4 does not, because they are absorbed via a passive process directly from the intestine. This may be a slight advantage for patients with cholestasis or severe pancreatic dysfunction. Only vitamin K1, however, is appropriate therapy for bleeding associated with warfarin and superwarfarin anticoagulation. Vitamin K2 is not used therapeutically.

Mechanism of action

Vitamin K antagonists, such as warfarin, produce their effect on blood coagulation by interfering with the cyclic interconversion of vitamin K and vitamin K 2,3-epoxide. Vitamin K is an essential cofactor necessary for the posttranslational carboxylation of the glutamic acid residues on the N-terminal portions of the specific clotting factors (II, VII, IX, and X) and anticoagulant proteins, such as protein C. This γ-glutamyl carboxylation results in a new amino acid, γ-carboxyglutamate, which through chelation of calcium ions causes the proteins to undergo a conformational change. This change in tertiary structure allows the four vitamin K–dependent clotting factors to become activated and bind to the negatively charged phospholipid membranes during clotting cascade activation.

Pharmacokinetics

The half-life of vitamin K1 is quite short—only 1.7 hours via the intravenous route and 3–5 hours via the oral route. When given orally, vitamin K1 is absorbed directly from the proximal small intestine in an energy-dependent and saturable process that requires the presence of bile salts. These kinetic features argue for administration in divided doses rather than larger, single daily doses. The typical starting point for adults with drug-induced hypoprothrombinemia is 2.5 to 10 mg of vitamin K1 orally, repeating in 12 to 48 hours if needed. In cases of ingestion of long-acting superwarfarin rodenticides (e.g., brodifacoum), therapy may be 125 mg/day for weeks or months. Practically speaking, because vitamin K1 is dispensed as 5-mg tablets, superwarfarin-poisoned patients may require 10 to 30 tablets every 6 hours.

Clinical Use

Vitamin K1 (phytonadione, Mephyton) is the form of vitamin K most often used therapeutically. Vitamin K1 is safe for use in infants, pregnant women, and patients with glucose-6-phosphate deficiency.

Safety Profile

Moderately toxic by subcutaneous route. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

VITAMIN K1 Preparation Products And Raw materials

Raw materials

Preparation Products

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VITAMIN K1 Suppliers

Nanjing Jiusi Pharmaceutical Technology Development Co., Ltd.
Tel
123
Email
jiusiyiyao2020@126.com
Country
China
ProdList
89
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
021-61984905-1 18016477331
Email
synchempharma@aliyun.com
Country
China
ProdList
6451
Advantage
55
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
9086
Advantage
60
Shanghai Standard Technology Co.,Ltd.
Tel
021-57127007-6622 15618937986
Fax
+86 (21) 5132-0077
Email
zhaok@nature-standard.com
Country
China
ProdList
3920
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 18521078705
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
20014
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4383
Advantage
58
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-87576359 17691182729
Fax
029-88380327
Email
1018@dideu.com
Country
China
ProdList
1982
Advantage
58
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View Lastest Price from VITAMIN K1 manufacturers

Hebei Yime New Material Technology Co., Ltd.
Product
Vitamin K 12001-79-5
Price
US $30.00/KG
Min. Order
1KG
Purity
30%
Supply Ability
20t/month
Release date
2021-08-03
shandong perfect biotechnology co.ltd
Product
Vitamin K 12001-79-5
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1000kg
Release date
2023-08-04
Hangzhou ICH Biofarm Co., Ltd
Product
VITAMIN K1 12001-79-5
Price
US $0.00-0.00/g
Min. Order
0.1g
Purity
99%HPLC
Supply Ability
500kg
Release date
2023-06-29

12001-79-5, VITAMIN K1Related Search:


  • vitamine K
  • VITAMIN K
  • Synkavite
  • 2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
  • VITAMIN K1 USP23
  • Kanavit
  • Vitamin K substances
  • C01628
  • 12001-79-5---VITAMIN K1
  • 6E)-1
  • 6-heptadien-3-one
  • 7-Diphenyl-4
  • Vitamin K (8CI, 9CI, ACI)
  • 12001-79-5
  • 184-80-0
  • Miscellaneous Natural Products
  • API