BAY707)

Product Name: BAY707)
CAS No.: 2109805-96-9
Chemical Name: BAY707)
Synonyms: BAY707);BAY-707 (BAY 707;BAY-707 free base;1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-
CBNumber: CB04844527
Molecular Formula: C15H20N4O2
Formula Weight: 288.34
MOL File: 2109805-96-9.mol

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BAY707) Property

Density: 1.225±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM)
pka: 14.36±0.40(Predicted)
form: Solid
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6562
Product name: BAY707
Purity: ≥98%(HPLC)
Packaging: 5
Price: $115
Updated: 2021/12/16

Tocris

Product number: 6562
Product name: BAY707
Purity: ≥98%(HPLC)
Packaging: 25
Price: $485
Updated: 2021/12/16

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BAY707) Chemical Properties,Usage,Production

Biological Activity

BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy.

in vivo

Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model.

target

IC50: 2.3 nM (MTH1/NUDT1)

storage

Store at -20°C

BAY707) Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY707) Suppliers

China 9 United States 4 Global 13

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 998
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4997
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5127
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Email: rdname@qq.com
Country: CHINA
ProdList: 35705
Advantage: 58

2109805-96-9, BAY707)Related Search:

BAY-707 (BAY 707

BAY707)

1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-

BAY-707 free base

2109805-96-9