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IKE

Product Name
IKE
CAS No.
1801530-11-9
Chemical Name
IKE
Synonyms
IKE);PUN-30119;Ferroptosis inducer IKE;Imidazole ketone erastin;Imidazole ketone erastin (PUN30119);Imidazole ketone erastin (Ferroptosis inducer IKE;IMIDAZOLE KETONE ERASTIN;FERROPTOSIS INDUCER IKE;IKE;3-(5-(2-(1H-Imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
CBNumber
CB04844901
Molecular Formula
C35H35ClN6O5
Formula Weight
655.14
MOL File
1801530-11-9.mol
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IKE Property

Boiling point:
886.5±75.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 10mg/mL,DMSO: 1mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.25mg/mL
form 
A crystalline solid
pka
6.12±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27088
Product name
Imidazole Ketone Erastin
Purity
≥98%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
27088
Product name
Imidazole Ketone Erastin
Purity
≥98%
Packaging
5mg
Price
$298
Updated
2024/03/01
Cayman Chemical
Product number
27088
Product name
Imidazole Ketone Erastin
Packaging
10mg
Price
$502
Updated
2024/03/01
DC Chemicals
Product number
DC22092
Product name
Imidazoleketoneerastin(IKE)
Purity
>98%
Packaging
100mg
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
DC22092
Product name
Imidazoleketoneerastin(IKE)
Purity
>98%
Packaging
250mg
Price
$1200
Updated
2021/12/16
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IKE Chemical Properties,Usage,Production

Description

Imidazole ketone erastin is an inducer of ferroptosis. It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter. Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC50 = 34 nM). It inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM). Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model.

Uses

PUN30119 is potent, metabolically stable inhibitor of system xc.

IKE Preparation Products And Raw materials

Raw materials

Preparation Products

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IKE Suppliers

Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1991
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
ATK CHEMICAL COMPANY LIMITED
Tel
021-51619050 13301662590
Fax
+86-21-51619052
Email
mandy@atkchemical.com
Country
China
ProdList
8026
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7267
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68

1801530-11-9, IKERelated Search:


  • IKE)
  • Imidazole ketone erastin (Ferroptosis inducer IKE
  • Ferroptosis inducer IKE
  • IMIDAZOLE KETONE ERASTIN;FERROPTOSIS INDUCER IKE;IKE
  • Imidazole ketone erastin
  • 4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
  • 3-(5-(2-(1H-Imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one
  • PUN-30119
  • Imidazole ketone erastin (PUN30119)
  • 1801530-11-9
  • C35H35ClN6O5