ChemicalBook > CAS DataBase List > Olutasidenib

Olutasidenib

Product Name: Olutasidenib
CAS No.: 1887014-12-1
Chemical Name: Olutasidenib
Synonyms: FT-2102;OLUTASIDENIB;Olutasidenib (FT-2102);Olutasidenib, 10 mM in DMSO;Olutasidenib (FT-2102) ，S8949;Olutasidenib (Synonyms: FT-2102);mutant,FT2102,inhibit,Isocitrate Dehydrogenase (IDH),Olutasidenib,2-HG,FT 2102,Inhibitor;(S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
CBNumber: CB04845034
Molecular Formula: C18H15ClN4O2
Formula Weight: 354.79
MOL File: 1887014-12-1.mol

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Olutasidenib Property

Boiling point:: 603.3±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A crystalline solid
pka: 10.44±0.70(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)23(2)18(16)25)14-8-11-7-12(19)3-5-15(11)22-17(14)24/h3-8,10,21H,1-2H3,(H,22,24)/t10-/m0/s1
InChIKey: NEQYWYXGTJDAKR-JTQLQIEISA-N
SMILES: C1(C#N)N(C)C(=O)C(N[C@H](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)=CC=1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0080183
Product name: Olutasidenib
Purity: 98.35%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0080183
Product name: Olutasidenib
Purity: 98.35%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0080183
Product name: Olutasidenib
Purity: 98.35%
Packaging: 25mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0080183
Product name: Olutasidenib
Purity: 98.35%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611286
Product name: Olutasidenib (FT-2102)
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

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Olutasidenib Chemical Properties,Usage,Production

Uses

Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1), with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively . Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) [1][2].

Mechanism of action

Olutasidenib specifically inhibits the mutant IDH1 enzyme, which reduces the accumulation of abnormal metabolites and promotes normal differentiation and maturation of cells. This targeted treatment approach aims to reduce tumor burden and improve patient outcomes.

in vivo

Olutasidenib (FT-2102, three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) exhibits potent anti-tumor activity in HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice^[2].

Animal Model:	HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice^[2].
Dosage:	12.5, 25, and 50 mg/kg.
Administration:	Three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals.
Result:	Showed a time and dose-dependent inhibition of 2-HG levels in in tumor. At the highest dose tested in these studies (50 mg/kg), treatment with FT-2102 inhibited 2-HG levels in the tumor by >90% for up to 24 hours after the last dose in the HCT116-IDH1-R132H/+ xenograft model.

IC 50

IDH1

References

[1] JM Watts, et al. A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
[2] Justin A. Caravella, et al. Structure-based design and identification of FT-2102 (olutasidenib), a potent mutant-selective IDH1 inhibitor. J Med Chem. 2020.

Olutasidenib Preparation Products And Raw materials

Raw materials

Preparation Products

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1887014-12-1, OlutasidenibRelated Search:

Olutasidenib (Synonyms: FT-2102)

Olutasidenib (FT-2102)

5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

OLUTASIDENIB

FT-2102

2-Pyridinecarbonitrile, 5-[[(1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl]amino]-1,6-dihydro-1-methyl-6-oxo-

mutant,FT2102,inhibit,Isocitrate Dehydrogenase (IDH),Olutasidenib,2-HG,FT 2102,Inhibitor

(S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

Olutasidenib, 10 mM in DMSO

Olutasidenib (FT-2102) ，S8949

1887014-12-1

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