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Olutasidenib

Product Name
Olutasidenib
CAS No.
1887014-12-1
Chemical Name
Olutasidenib
Synonyms
FT-2102;OLUTASIDENIB;Olutasidenib (FT-2102);Olutasidenib, 10 mM in DMSO;Olutasidenib (FT-2102) ，S8949;Olutasidenib (Synonyms: FT-2102);mutant,FT2102,inhibit,Isocitrate Dehydrogenase (IDH),Olutasidenib,2-HG,FT 2102,Inhibitor;(S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
CBNumber
CB04845034
Molecular Formula
C18H15ClN4O2
Formula Weight
354.79
MOL File
1887014-12-1.mol
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Olutasidenib Property

Boiling point:
603.3±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A crystalline solid
pka
10.44±0.70(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)23(2)18(16)25)14-8-11-7-12(19)3-5-15(11)22-17(14)24/h3-8,10,21H,1-2H3,(H,22,24)/t10-/m0/s1
InChIKey
NEQYWYXGTJDAKR-JTQLQIEISA-N
SMILES
C1(C#N)N(C)C(=O)C(N[C@H](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)=CC=1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
25mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
50mg
Price
$1100
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611286
Product name
Olutasidenib (FT-2102)
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
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Olutasidenib Chemical Properties,Usage,Production

Uses

Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1), with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively . Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) [1][2].

Mechanism of action

Olutasidenib specifically inhibits the mutant IDH1 enzyme, which reduces the accumulation of abnormal metabolites and promotes normal differentiation and maturation of cells. This targeted treatment approach aims to reduce tumor burden and improve patient outcomes.

in vivo

Olutasidenib (FT-2102, three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) exhibits potent anti-tumor activity in HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice[2].

Animal Model:HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice[2].
Dosage:12.5, 25, and 50 mg/kg.
Administration:Three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals.
Result:Showed a time and dose-dependent inhibition of 2-HG levels in in tumor.
At the highest dose tested in these studies (50 mg/kg), treatment with FT-2102 inhibited 2-HG levels in the tumor by >90% for up to 24 hours after the last dose in the HCT116-IDH1-R132H/+ xenograft model.

IC 50

IDH1

References

[1] JM Watts, et al. A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
[2] Justin A. Caravella, et al. Structure-based design and identification of FT-2102 (olutasidenib), a potent mutant-selective IDH1 inhibitor. J Med Chem. 2020.

Olutasidenib Preparation Products And Raw materials

Raw materials

Preparation Products

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Olutasidenib Suppliers

CHINA 56 United States 4 Global 60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1887014-12-1, OlutasidenibRelated Search:


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  • (S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
  • (S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
  • Olutasidenib, 10 mM in DMSO
  • Olutasidenib (FT-2102) ，S8949
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  • API