ChemicalBook > CAS DataBase List > FT-113

FT-113

Product Name: FT-113
CAS No.: 1630808-89-7
Chemical Name: FT-113
Synonyms: FT-113;FT113;F113;FT 113;FT113, 10 mM in DMSO;FT 113,Fatty Acid Synthase (FASN),Inhibitor,FT-113,FT113,inhibit;Methanone, [4-[4-(6-fluoro-2-benzoxazolyl)benzoyl]-1-piperazinyl](1-hydroxycyclopropyl)-;(4-(4-(6-Fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
CBNumber: CB04857314
Molecular Formula: C22H20FN3O4
Formula Weight: 409.41
MOL File: 1630808-89-7.mol

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FT-113 Property

Boiling point:: 637.6±55.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 62.5 mg/mL (152.66 mM; Need ultrasonic)
pka: 13.92±0.20(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C22H20FN3O4/c23-16-5-6-17-18(13-16)30-19(24-17)14-1-3-15(4-2-14)20(27)25-9-11-26(12-10-25)21(28)22(29)7-8-22/h1-6,13,29H,7-12H2
InChIKey: DSTWHRGOCUOKDE-UHFFFAOYSA-N
SMILES: C(N1CCN(C(=O)C2=CC=C(C3=NC4=CC=C(F)C=C4O3)C=C2)CC1)(C1(O)CC1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087124
Product name: FT113
Purity: 99.18%
Packaging: 5mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0087124
Product name: FT113
Purity: 99.18%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0087124
Product name: FT113
Purity: 99.18%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-0087124
Product name: FT113
Purity: 99.18%
Packaging: 100mg
Price: $1400
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573431
Product name: FT113
Packaging: 250mg
Price: $1949.9
Updated: 2021/12/16

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FT-113 Chemical Properties,Usage,Production

Uses

FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1].

in vivo

FT113 (5 mg/kg, p.o.) exhibits potent oral bioavailability of 95% and 84% in mice and rats, respectively^[1].
? FT113 (5, 25, or 50 mg/kg, p.o., twice daily for 16 days) increases malonyl-CoA concentration in tumors, inhibits tumor growth in a dose-dependent manner in mice^[1].

Animal Model:	Athymic nude mice bearing MV-411 cells^[1]
Dosage:	5, 25, or 50 mg/kg
Administration:	P.O., twice daily for 16 days
Result:	Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.

References

[1] Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006. DOI:10.1016/j.bmcl.2019.02.012

FT-113 Preparation Products And Raw materials

Raw materials

Preparation Products

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1630808-89-7, FT-113Related Search:

FT-113

FT113;F113;FT 113

Methanone, [4-[4-(6-fluoro-2-benzoxazolyl)benzoyl]-1-piperazinyl](1-hydroxycyclopropyl)-

FT 113,Fatty Acid Synthase (FASN),Inhibitor,FT-113,FT113,inhibit

(4-(4-(6-Fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone

FT113, 10 mM in DMSO

1630808-89-7