Elenbecestat(E2609)

Product Name: Elenbecestat(E2609)
CAS No.: 1388651-30-6
Chemical Name: Elenbecestat(E2609)
Synonyms: Elenbecestat(E26090;Elenbecestat(E2609);Elenbecestat, 10 mM in DMSO;Alzheimer's disease,inhibit,Beta-secretase,E-2609,Inhibitor,Elenbecestat,E 2609,β-Secretase,BACE-1,BACE;N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, N-[3-[(4aS,5R,7aS)-2-amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)-
CBNumber: CB04868677
Molecular Formula: C19H18F3N5O2S
Formula Weight: 437.44
MOL File: 1388651-30-6.mol

More

Less

Elenbecestat(E2609) Property

Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 250 mg/mL (571.51 mM)
pka: 9.06±0.70(Predicted)
form: Solid
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0031645
Product name: Elenbecestat
Purity: 99.77%
Packaging: 5mg
Price: $295
Updated: 2021/12/16

ChemScene

Product number: CS-0031645
Product name: Elenbecestat
Purity: 99.77%
Packaging: 10mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0031645
Product name: Elenbecestat
Purity: 99.77%
Packaging: 25mg
Price: $965
Updated: 2021/12/16

ChemScene

Product number: CS-0031645
Product name: Elenbecestat
Purity: 99.77%
Packaging: 50mg
Price: $1640
Updated: 2021/12/16

ChemScene

Product number: CS-0031645
Product name: Elenbecestat
Purity: 99.77%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

More

Less

Elenbecestat(E2609) Chemical Properties,Usage,Production

Uses

Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research[1][2].

in vivo

Elenbecestat (E2609; 0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates^[2].
Elenbecestat displays the plasma half-life of 12-16 hours after once daily dosing^[1].

Animal Model:	Cynomolgus monkeys (Pharmacokinetic analysis)^[2]
Dosage:	0.3 mg/kg; 1 mg/kg; 3 mg/kg; 30 mg/kg
Administration:	Oral administration
Result:	Potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF.

IC 50

BACE1

References

[1] Kumar D, et al.Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452. DOI:10.1016/j.ejmech.2018.02.035
[2] A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer’s & Dementia, 8(4), P224.

Elenbecestat(E2609) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Elenbecestat(E2609) Suppliers

China 34 United States 4 Global 38

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1112
Advantage: 64

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29662
Advantage: 68

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1945
Advantage: 55

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

1388651-30-6, Elenbecestat(E2609)Related Search:

Elenbecestat(E2609)

Elenbecestat(E26090

Alzheimer's disease,inhibit,Beta-secretase,E-2609,Inhibitor,Elenbecestat,E 2609,β-Secretase,BACE-1,BACE

2-Pyrazinecarboxamide, N-[3-[(4aS,5R,7aS)-2-amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)-

N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Elenbecestat, 10 mM in DMSO

1388651-30-6