rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

Product Name: rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
CAS No.: 87304-15-2
Chemical Name: rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
Synonyms: rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine;L-Leucine, N-[(2S,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-;(2S)-2-[(2S,3R)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
CBNumber: CB04888976
Molecular Formula: C21H32N2O6
Formula Weight: 408.49
MOL File: 87304-15-2.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Chemical Properties,Usage,Production

Description

E3 Ligase ligand 9 targets ubiquitin-protein ligases in order to activate the E3 ubiquitin ligase. It can then treat metabolic disorders and psychiatric disorders.

Uses

E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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87304-15-2, rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucineRelated Search:

rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine

L-Leucine, N-[(2S,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-

(2S)-2-[(2S,3R)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid

87304-15-2