ChemicalBook > CAS DataBase List > N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

Product Name
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
CAS No.
1630936-95-6
Chemical Name
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
Synonyms
ML-396;VU 0422288;ML396 >=98% (HPLC);VU0422288 (Synonyms: ML396);N-(3-Chloro-4-((5-chloropyridin-2-yl)oxy)phenyl)picolinamide;N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-
CBNumber
CB04902919
Molecular Formula
C17H11Cl2N3O2
Formula Weight
360.19
MOL File
1630936-95-6.mol
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N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Property

Melting point:
154-158°C
Boiling point:
422.6±45.0 °C(Predicted)
Density 
1.445±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
10.42±0.70(Predicted)
color 
Light Red to Red
InChI
1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
InChIKey
MZRLPXFGQKQHST-UHFFFAOYSA-N
SMILES
O=C(NC1=CC=C(OC2=NC=C(Cl)C=C2)C(Cl)=C1)C3=NC=CC=C3
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Eye Irrit. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29167
Product name
ML-396
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
29167
Product name
ML-396
Packaging
25mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
29167
Product name
ML-396
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29167
Product name
ML-396
Packaging
10mg
Price
$199
Updated
2024/03/01
Tocris
Product number
5378
Product name
VU0422288
Purity
≥98%(HPLC)
Packaging
10
Price
$205
Updated
2021/12/16
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N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Chemical Properties,Usage,Production

Uses

VU 0422288 is a metabotropic glutamate receptor 7 (mGlu7) positive allosteric modulators.

Biological Activity

ML396 is a potent positive allosteric modulator or metabotropic glutamate receptors group III (mGlu group III PAM). ML396 was used to study the biology of mGlu7.

in vivo

VU0422288 (30 mg/kg; i.p.; once daily for 17 days) rescues synaptic plasticity defects and learning and memory phenotypes, reduces the number of apneas in Mecp2+/- mice, while VU0422288 has no effect in Mecp2+/+animals[2].
VU0422288 (10 mg/kg; i.p.; single dose) exhibis a plasma/brain partitioning coefficient of 1.67 in adult male Sprague-Dawley rats, with predicted unbound brain concentration of about 40 nM[2].

IC 50

mGluR4: 108 nM (EC50); mGluR7: 146 nM (EC50); mGluR8: 128 nM (EC50)

storage

Store at +4°C

N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide Suppliers

China 27 United Kingdom 1 United States 5 USA 1 Global 34
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
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3008007409@qq.com
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China
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MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
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1014988033@qq
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sales@linyuepharm.com
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China
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5040
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
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sales@glpbio.cn
Country
China
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6777
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32470
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11218
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
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QQ:3607245178
Email
15151849396@163.com
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China
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989
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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3525679403@qq.com
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China
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4899
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
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marketing@energy-chemical.com
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China
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44918
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Jinan Jiuli Biotechnology Co. , Ltd.
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15865264761
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486064515@qq.com
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China
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4858
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1630936-95-6, N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamideRelated Search:


  • N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
  • VU 0422288
  • ML-396
  • ML396 >=98% (HPLC)
  • VU0422288 (Synonyms: ML396)
  • 2-Pyridinecarboxamide, N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-
  • N-(3-Chloro-4-((5-chloropyridin-2-yl)oxy)phenyl)picolinamide
  • 1630936-95-6