ChemicalBook > CAS DataBase List > Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
- Product Name
- Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
- CAS No.
- 1926163-57-6
- Chemical Name
- Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
- Synonyms
- Z-VRPR-FMK trifluoroacetate;Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt;L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-
- CBNumber
- CB04915751
- Molecular Formula
- C31H49FN10O6
- Formula Weight
- 676.78
- MOL File
- 1926163-57-6.mol
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Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 11.06±0.46(Predicted)
- Sequence
- Z-Val-Arg-Pro-{DL-Arg}-{Fluoromethylketone}
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N-Bromosuccinimide Price
Chem-Impex
- Product number
- 32776
- Product name
- Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
- Packaging
- 500MG
- Price
- $310.5
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 32776
- Product name
- Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
- Packaging
- 1MG
- Price
- $550
- Updated
- 2021/12/16
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Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Chemical Properties,Usage,Production
Uses
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1].
in vivo
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (37.5 M*0.2 mL; every other day for 12 days) inhibits the growth of the tumor in mouse[1].
| Animal Model: | 4-6 weeks, 16-20 g, Female BALB/c nude mice (OCI-LY10 cells)[1] |
| Dosage: | 37.5 M*0.2 mL |
| Administration: | Every other day for 12 days |
| Result: | Inhibited the growth of the xenografts and decreased the expression of P65. |
References
[1] Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. PMID:31934017
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Preparation Products And Raw materials
Raw materials
Preparation Products
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Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt Suppliers
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