MC180295

Product Name: MC180295
CAS No.: 2237942-08-2
Chemical Name: MC180295
Synonyms: MC180295;(rel)-MC180295;MC-180295;MC 180295;MC180295, 10 mM in DMSO;MC180295 ((REL)-MC180295);MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor;Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-
CBNumber: CB04923806
Molecular Formula: C17H18N4O3S
Formula Weight: 358.41
MOL File: 2237942-08-2.mol

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MC180295 Property

Boiling point:: 623.8±65.0 °C(Predicted)
Density: 1.462±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (279.01 mM)
form: Solid
pka: 2.40±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0081067
Product name: MC180295
Purity: 98.47%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0081067
Product name: MC180295
Purity: 98.47%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573229
Product name: MC180295
Purity: >98%
Packaging: 100mg
Price: $1802
Updated: 2021/12/16

ChemScene

Product number: CS-0081067
Product name: MC180295
Purity: 98.47%
Packaging: 50mg
Price: $2850
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573229
Product name: MC180295
Purity: >98%
Packaging: 250mg
Price: $3136.5
Updated: 2021/12/16

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MC180295 Chemical Properties,Usage,Production

Uses

MC180295 can be useful in combination therapy of BET proteolysis targeting chimeric mol. with CDK9 inhibitor against human multiple myeloma cells.

Biological Activity

MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with IC50 of 5 nM, at least 22-fold selective for CDK9 over other CDKs.

in vivo

MC180295 has antitumor and immunoallergic activity.

target

Target	Value
CDK9-Cyclin T1 (Cell-free assay)	5 nM
CDK4-Cyclin D (Cell-free assay)	112 nM
CDK1-Cyclin B (Cell-free assay)	138 nM
CDK5-P35 < br/> (Cell-free assay)	159 nM
CDK5-P25 (Cell-free assay)	186 nM

MC180295 Preparation Products And Raw materials

Raw materials

Preparation Products

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MC180295 Suppliers

China 25 United States 4 Global 29

ShangHai Caerulum Pharma Discovery Co., Ltd.

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2237942-08-2, MC180295Related Search:

MC180295 ((REL)-MC180295)

MC180295

MC-180295;MC 180295

(rel)-MC180295

Methanone, [4-amino-2-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]-5-thiazolyl](2-nitrophenyl)-, rel-

MC180295,MC 180295,Cyclin dependent kinase,MC-180295,CDK,inhibit,Inhibitor

MC180295, 10 mM in DMSO

2237942-08-2