ETILEFRINE-D5
- Product Name
- ETILEFRINE-D5
- CAS No.
- 709-55-7
- Chemical Name
- ETILEFRINE-D5
- Synonyms
- S 40032;Etilefrin;S 40032-7;Aids001656;Etilephrine;Aids-001656;dl-Etilefrin;Etiladrianol;Etilefrin-d5;ETILEFRINE-D5
- CBNumber
- CB0495639
- Molecular Formula
- C10H15NO2
- Formula Weight
- 181.23
- MOL File
- 709-55-7.mol
ETILEFRINE-D5 Property
- Melting point:
- 147-148°
- Boiling point:
- 314.35°C (rough estimate)
- Density
- 1.0918 (rough estimate)
- refractive index
- 1.5464 (estimate)
- pka
- 9.81±0.10(Predicted)
- LogP
- 3.2 at 25℃ and pH5.5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0008685
- Product name
- ETILEFRINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $136.5
- Updated
- 2021/12/16
ETILEFRINE-D5 Chemical Properties,Usage,Production
Originator
Circupon,Troponwerke,W. Germany
Uses
Etilefrin is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Uses
ETILEFRINE-D5 is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Definition
ChEBI: 3-[2-(ethylamino)-1-hydroxyethyl]phenol is a member of phenols.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
ETILEFRINE-D5 Preparation Products And Raw materials
Raw materials
Preparation Products
ETILEFRINE-D5 Suppliers
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