7-Hydroxy-1-indanone
Uses- Product Name
- 7-Hydroxy-1-indanone
- CAS No.
- 6968-35-0
- Chemical Name
- 7-Hydroxy-1-indanone
- Synonyms
- Nsc64459;1-Oxo-7-indanol;7-Hydroxyindan-1-one;7-HYDROXY-1-INDANONE;7-Hydroxy-1-indanone>7-Hydroxy-1-indanone 97%;7-HYDROXY-1-INDANONE 97;7-Hydroxy-2,3-dihydroinden-1-one;2,3-Dihydro-7-hydroxy-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-7-hydroxy-
- CBNumber
- CB0505141
- Molecular Formula
- C9H8O2
- Formula Weight
- 148.16
- MOL File
- 6968-35-0.mol
7-Hydroxy-1-indanone Property
- Melting point:
- 109-113 °C (lit.)
- Boiling point:
- 310℃
- Density
- 1.305
- Flash point:
- 131℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Slightly)
- form
- Solid
- pka
- 10.27±0.20(Predicted)
- color
- White to Light yellow to Light orange
- λmax
- 311nm(Cyclohexane)(lit.)
- InChI
- InChI=1S/C9H8O2/c10-7-3-1-2-6-4-5-8(11)9(6)7/h1-3,10H,4-5H2
- InChIKey
- HFMZPBSZKCDKOR-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2O)CC1
- CAS DataBase Reference
- 6968-35-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 587052
- Product name
- 7-Hydroxy-1-indanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $133.95
- Updated
- 2025/07/31
- Product number
- H1526
- Product name
- 7-Hydroxy-1-indanone
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- H953823
- Product name
- 7-Hydroxy-1-indanone
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- H953823
- Product name
- 7-Hydroxy-1-indanone
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W7940
- Product name
- 7-Hydroxy-1-indanone
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
7-Hydroxy-1-indanone Chemical Properties,Usage,Production
Uses
7-Hydroxy-1-indanone is a ketone derivative with wide applications in medicinal chemistry and organic synthesis.
Synthesis
491-37-2
6968-35-0
General procedure for the synthesis of 7-hydroxy-1-indanone from 2,3-dihydrochromen-4-one: 37.0 g (278 mmol) of aluminum chloride was mixed with 3.70 g (61.3 mmol) of sodium chloride, and the mixture was heated at 150 °C until completely dissolved. Subsequently, 6.40 g (43.2 mmol) of commercially available 2,3-dihydro-4H-chromen-4-one (preheated to 50 °C to dissolve) was added and the reaction mixture was stirred at 200 °C for 20 minutes. After completion of the reaction, the reaction mixture was cooled to a gelatinous consistency, pre-prepared ice-cold hydrochloric acid (200 ml made by mixing 100 ml of concentrated hydrochloric acid with ice) was slowly added and stirred continuously for 30 minutes. The reaction mixture was extracted with dichloromethane and the organic layer was separated. The aqueous layer was filtered and the filtrate was again extracted with dichloromethane. All organic layers were combined, washed sequentially with water and brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the resulting crude product was purified by silica gel column chromatography (Wakogel C-100, eluent hexane-ethyl acetate gradient) to give 4.82 g (32.6 mmol, 75.2% yield) of the target product 7-hydroxy-1-indanone.
References
[1] Patent: EP1426365, 2004, A1. Location in patent: Page 183
[2] Tetrahedron Letters, 2011, vol. 52, # 9, p. 960 - 963
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 3, p. 512 - 515
[4] ChemMedChem, 2018, vol. 13, # 18, p. 1949 - 1956
[5] European Journal of Organic Chemistry, 2016, vol. 2016, # 20, p. 3365 - 3372
7-Hydroxy-1-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Hydroxy-1-indanone manufacturers
- Product
- 7-HYDROXY-1-INDANONE 6968-35-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 7-Hydroxy-1-indanone 6968-35-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 7-Hydroxy-1-indanone 6968-35-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09