3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT&

Product Name: 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT&
CAS No.: 345957-19-9
Chemical Name: 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT&
Synonyms: Liothyronine sodium hydrate;3,3',5-Triiodo-L-thyronine (sodium salt hydrate);3,3μ,5-Triiodo-L-thyronine hydrate sodium salt;3,3',5-Triiodo-L-thyronine sodium salt hydrate 95%;3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& USP/EP/BP;3,3′,5-Triiodo-L-thyronine sodium salt hydrate;Sodium(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoatehydrate(1:1:1)
CBNumber: CB0505510
Molecular Formula: C15H11I3NO4Na
Formula Weight: 672.96
MOL File: 345957-19-9.mol

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3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Property

Melting point:: 205 °C (dec.)(lit.)
storage temp.: Store at -20°C
solubility: DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml
form: A crystalline solid
color: white to light pink
optical activity: [α]22/D +21.5°, c = 2 in 1 N HCl: ethanol, 1:2
InChI: 1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-4,6,12,20H,5,19H2,(H,21,22);;1H2/q;+1;/p-1/t12-;;/m0../s1
InChIKey: IRGJMZGKFAPCCR-LTCKWSDVSA-M
SMILES: O.[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
Storage Class: 13 - Non Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16028
Product name: 3,3'',5-Triiodo-L-thyronine (sodium salt hydrate)
Purity: ≥98%
Packaging: 100mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16028
Product name: 3,3'',5-Triiodo-L-thyronine (sodium salt hydrate)
Purity: ≥98%
Packaging: 250mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 16028
Product name: 3,3'',5-Triiodo-L-thyronine (sodium salt hydrate)
Purity: ≥98%
Packaging: 500mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 16028
Product name: 3,3'',5-Triiodo-L-thyronine (sodium salt hydrate)
Purity: ≥98%
Packaging: 1g
Price: $214
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: AAA0004052
Product name: 3,3',5-TRIIODO-L-THYRONINE SODIUM SALT HYDRATE
Purity: 95.00%
Packaging: 100MG
Price: $640.57
Updated: 2021/12/16

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3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Chemical Properties,Usage,Production

Description

3,3'',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5''-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (K_is = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 μM.

Uses

Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

IC 50

Human Endogenous Metabolite

References

[1] Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. DOI:10.1016/0304-3835(94)90274-7
[2] Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. DOI:10.1006/bbrc.1993.2055
[3] Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. DOI:10.1016/j.bmc.2012.03.056

3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Preparation Products And Raw materials

Raw materials

Preparation Products

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3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Suppliers

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345957-19-9, 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT&Related Search:

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345957-19-9

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