5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%
- Product Name
- 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%
- CAS No.
- 214894-89-0
- Chemical Name
- 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%
- Synonyms
- 5-(bromomethyl)-2,3-dihydro-1,4-Benzodioxin;5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine;1,4-Benzodioxin, 5-(bromomethyl)-2,3-dihydro-;5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine;5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%
- CBNumber
- CB0506481
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 214894-89-0.mol
5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97% Property
- Boiling point:
- 295.7±29.0 °C(Predicted)
- Density
- 1.549±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0328397
- Product name
- 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.87
- Updated
- 2021/12/16
- Product number
- 35109
- Product name
- 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- 0931AB
- Product name
- 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine
- Packaging
- 100mg
- Price
- $646
- Updated
- 2021/12/16
- Product number
- 35109
- Product name
- 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $692
- Updated
- 2021/12/16
- Product number
- A274764
- Product name
- 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1218
- Updated
- 2021/12/16
5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97% Chemical Properties,Usage,Production
Synthesis
274910-19-9
214894-89-0
The general procedure for the synthesis of 5-bromomethyl-2,3-dihydro-1,4-benzodioxole from (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol was as follows: (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol (3.75 g, 32.3 mmol) was dissolved in ethyl ether (80 mL) and the solution was cooled to 0 °C. Phosphorus tribromide (3.67 mL, 38.8 mmol) was added slowly and dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 10 minutes, then brought to room temperature and stirred for 1 hour. Upon completion of the reaction, water (10 mL) was carefully added to quench the excess phosphorus tribromide. The mixture was diluted with ether and washed with water (3 x 50 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 5-bromomethyl-2,3-dihydro-1,4-benzodioxole as a brown solid (4.61 g, 62% yield). The product was characterized by 1H NMR (CDCl3): δ 6.91-6.77 (m, 3H), 4.52 (s, 2H), 4.35-4.33 (m, 2H), 4.29-4.27 (m, 2H). Mass spectrum measured value: [M + H-Br] = 149.5.
References
[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0076
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1797 - 1809
5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97% Preparation Products And Raw materials
Raw materials
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