ChemicalBook > CAS DataBase List > PKI 166 hydrochloride
PKI 166 hydrochloride
- Product Name
- PKI 166 hydrochloride
- CAS No.
- 2230253-82-2
- Chemical Name
- PKI 166 hydrochloride
- Synonyms
- PKI 166 hydrochloride;PKI 166 hydrochloride,PKI166 hydrochloride;(R)-4-(4-((1-Phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenol hydrochloride , PKI-166 hydrochloride
- CBNumber
- CB05185856
- Molecular Formula
- C20H19ClN4O
- Formula Weight
- 366.85
- MOL File
- 2230253-82-2.mol
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PKI 166 hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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N-Bromosuccinimide Price
Tocris
- Product number
- 4941
- Product name
- PKI166hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $185
- Updated
- 2021/12/16
Usbiological
- Product number
- 256278
- Product name
- PKI 166 hydrochloride
- Packaging
- 10mg
- Price
- $475
- Updated
- 2021/12/16
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PKI 166 hydrochloride Chemical Properties,Usage,Production
Biological Activity
PKI-166 hydrochloride is a potent, selective, and orally bioactive EGFR tyrosine kinase inhibitor with IC50 of 0.7 nM.
in vivo
PKI-166 hydrochloride (100 mg/kg; po; daily; for 29 days) inhibits of pancreatic cancer growth.
p>
Animal Model: < /td> | Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks) |
Dosage: < /td> | 100 mg/kg |
Administration: | Oral administration; daily; for 29 days |
Result: | Significantly decreased median tumor volume. |
target
IC50: 0.7 nM (EGFR tyrosine kinase)
storage
Store at +4°C
PKI 166 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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PKI 166 hydrochloride Suppliers
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- United States
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