ChemicalBook > CAS DataBase List > PF429242 dihydrochloride

PF429242 dihydrochloride

Product Name
PF429242 dihydrochloride
CAS No.
2248666-66-0
Chemical Name
PF429242 dihydrochloride
Synonyms
PF 429242-HCl;PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242
CBNumber
CB05419810
Molecular Formula
C25H36ClN3O2
Formula Weight
446.03
MOL File
2248666-66-0.mol
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PF429242 dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15140
Product name
PF-429242 (hydrochloride)
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15140
Product name
PF-429242 (hydrochloride)
Packaging
25mg
Price
$547
Updated
2024/03/01
Cayman Chemical
Product number
15140
Product name
PF-429242 (hydrochloride)
Packaging
5mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
15140
Product name
PF-429242 (hydrochloride)
Packaging
10mg
Price
$243
Updated
2024/03/01
ChemScene
Product number
CS-6890
Product name
PF-429242 dihydrochloride
Purity
98.08%
Packaging
25mg
Price
$336
Updated
2021/12/16
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PF429242 dihydrochloride Chemical Properties,Usage,Production

Description

PF-429242 is an inhibitor of site-1 protease with an IC50 value of 170 nM for human recombinant site-1 protease. It is selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM. PF-429242 completely inhibits proteolytic processing and nuclear translocation of sterol regulatory element-binding protein (SREBP) in HepG2 cells at a concentration of 10 μM. It also reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells and reduces cholesterol and fatty acid synthesis in CD-1 mice. PF-429242 inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells. It also reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively).

storage

Desiccate at RT

PF429242 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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PF429242 dihydrochloride Suppliers

China 26 United States 6 Global 32
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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Beijing Solarbio Science & Tecnology Co., Ltd.
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Chuzhou KeMail Chemical Technology Co., Ltd
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Shanghai Hongye Biotechnology Co. Ltd
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Fan De(Beijing) Biotechnology Co., Ltd.
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liming@bio-fount.com
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Zhejiang J&C Biological Technology Co.,Limited
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Wuxi Donghe Pharmaceutical Technology Co., Ltd.
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Guangzhou Younan Technology Co., Ltd
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InvivoChem
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TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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RD International Technology Co., Limited
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2248666-66-0, PF429242 dihydrochlorideRelated Search:


  • PF 429242-HCl
  • PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242
  • 2248666-66-0