Propargyl-PEG5-Br
- Product Name
- Propargyl-PEG5-Br
- CAS No.
- 1287660-83-6
- Chemical Name
- Propargyl-PEG5-Br
- Synonyms
- Propargyl-P5-Br;Propargyl-PEG5-Br;Propargyl-PEG5-bromide;1-Bromo-3,6,9,12,15-pentaoxaoctadec-17-yne;3,6,9,12,15-Pentaoxaoctadec-17-yne, 1-bromo-;Propargyl-PEG5-Br/3,6,9,12,15-Pentaoxaoctadec-17-yne, 1-bromo-
- CBNumber
- CB05428119
- Molecular Formula
- C13H23BrO5
- Formula Weight
- 339.22
- MOL File
- 1287660-83-6.mol
Propargyl-PEG5-Br Property
- Boiling point:
- 377.4±37.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B-1403
- Product name
- Propargyl-PEG5-Br
- Purity
- 97%
- Packaging
- 1g
- Price
- $550
- Updated
- 2021/12/16
Propargyl-PEG5-Br Chemical Properties,Usage,Production
Uses
Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG5-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1009.
Propargyl-PEG5-Br Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG5-Br manufacturers
- Product
- Propargyl-PEG5-Br 1287660-83-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-03
- Product
- Propargyl-PEG5-bromide 1287660-83-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26