3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride
Application- Product Name
- 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride
- CAS No.
- 855778-84-6
- Chemical Name
- 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride
- Synonyms
- Tretinoin Impurity 14;Zavegepant Impurity 2 HCl;3-Piperidin-4-yl-quinolin-2(1H)-one HCl;3-(4-Piperidyl)quinolin-2(1H)-one Hydrochloride;3-(4-piperidyl)-1H-quinolin-2-one hydrochloride;3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride
- CBNumber
- CB05441444
- Molecular Formula
- C14H17ClN2O
- Formula Weight
- 264.75
- MOL File
- 855778-84-6.mol
3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Property
- InChI
- InChI=1S/C14H16N2O.ClH/c17-14-12(10-5-7-15-8-6-10)9-11-3-1-2-4-13(11)16-14;/h1-4,9-10,15H,5-8H2,(H,16,17);1H
- InChIKey
- BAPAUBKDZOEWJL-UHFFFAOYSA-N
- SMILES
- O=C1NC2=CC=CC=C2C=C1C1CCNCC1.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Chemical Properties,Usage,Production
Application
3-(piperidin-4-yl)-1,2-dihydroquinoline-2-one hydrochloride can be used as an important intermediate in the synthesis of new CGRP antagonist compounds.
Hazard
3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride has acute oral toxicity, it causes skin irritation and serious eye irritation.
Synthesis
A stirred solution of tert-butyl 4-(4-hydroxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-piperidine-1-carboxylate (5.60 g, 16.2 mmol) in ethyl acetate (70 mL) was treated with HCl/dioxane (4N, 40 mmol, 10 mL). The mixture was stirred at room temperature for 45 minutes. Then HCl/dioxane (4N, 120 mmol, 30 mL) was added and stirring was continued for 16 hours at room temperature. The resulting solid was collected by filtration and washed with ethyl acetate. It was then suspended in 5% water-isopropanol (100 mL) and the mixture was warmed to reflux and stirred for 20 minutes. The mixture was cooled to room temperature and stirred at room temperature for 16 hours. The solid was collected by filtration, washed with isopropanol and dried under high vacuum. 3-(Piperidin-4-yl)-1,2-dihydroquinolin-2-one hydrochloride was obtained in 75% yield as a white solid.
3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Suppliers
- Tel
- 18866891188; 18866891188
- zhaojiangxia@shiningpharm.com
- Country
- China
- ProdList
- 185
- Advantage
- 58
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
- ProdList
- 492
- Advantage
- 55
- Tel
- 18866895588
- Fax
- 0531-82777287
- dingjiaying@shiningpharm.com
- Country
- China
- ProdList
- 176
- Advantage
- 55
- Tel
- +86-571-85224801; 13588483690
- Fax
- 0571-85241599
- chemipanda2010@163.com
- Country
- China
- ProdList
- 111
- Advantage
- 62
- Tel
- 17813018085
- 181367029@qq.com
- Country
- China
- ProdList
- 62
- Advantage
- 58
- Tel
- 15269103900
- suchangzhou@shiningpharm.com
- Country
- China
- ProdList
- 356
- Advantage
- 58
- Tel
- 13636419861 13636419861
- alan@covapharm.com
- Country
- China
- ProdList
- 240
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 0551-68779238 18056025720
- sales3@lcywhx.com
- Country
- China
- ProdList
- 148
- Advantage
- 57
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
View Lastest Price from 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride manufacturers
- Product
- 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride 855778-84-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-10-23
- Product
- 3-(Piperidin-4-yl)quinolin-2(1H)-one hydrochloride 855778-84-6
- Price
- US $2.20-8.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-08
- Product
- 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride 855778-84-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01