NUC-3373

Product Name: NUC-3373
CAS No.: 1332837-31-6
Chemical Name: NUC-3373
Synonyms: NUC-3373;nucleotide analog NUC-3373;5-FU analog prodrug NUC-3373;Fosifloxuridine nafalbenamide;NUC3373(Fosifloxuridine nafalbenamide);phosphoramidate-FUDR-MP prodrug NUC-3373;Fosifloxuridine nafalbenamide, 10 mM in DMSO;L-Alanine, N-(2'-deoxy-5-fluoro-P-1-naphthalenyl-5'-uridylyl)-, phenylmethyl ester;5-FU ANALOG PRODRUG NUC-3373; NUCLEOTIDE ANALOG NUC-3373; PHOSPHORAMIDATE-FUDR-MP PRODRUG NUC-3373;Benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate
CBNumber: CB05466546
Molecular Formula: C29H29FN3O9P
Formula Weight: 613.54
MOL File: 1332837-31-6.mol

More

Less

NUC-3373 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (162.99 mM; Need ultrasonic)
form: Solid
pka: 7.63±0.10(Predicted)
color: White to off-white
InChIKey: BIOWRMNRHMERIO-VPUYLDKDNA-N
SMILES: O(C1=CC=CC2C=CC=CC1=2)P(=O)(N[C@@H](C)C(=O)OCC1C=CC=CC=1)OC[C@@H]1[C@H](C[C@H](N2C=C(F)C(=O)NC2=O)O1)O |&1:14,28,29,31,r|

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

DC Chemicals

Product number: DC26034
Product name: NUC3373(Fosifloxuridinenafalbenamide)
Purity: >98%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC26034
Product name: NUC3373(Fosifloxuridinenafalbenamide)
Purity: >98%
Packaging: 25mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC26034
Product name: NUC3373(Fosifloxuridinenafalbenamide)
Purity: >98%
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

More

Less

NUC-3373 Chemical Properties,Usage,Production

Uses

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch[1][2].

in vivo

Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models^[2].

References

[1] Fiona G. McKissock, et al. Abstract 1848: NUC-3373 induces ER stress and the release of damage associated molecular patterns in colorectal cancer cells. Cancer Res August 15 2020 (80) (16 Supplement) 1848.
[2] Essam A. Ghazaly, et al. Abstract B46: NUC-3373: A novel pyrimidine nucleotide analogue that overcomes key cancer drug resistance limiting patient survival. Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) B46.

NUC-3373 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NUC-3373 Suppliers

China 27 United States 2 Global 29

Shanghai Fulaiyide Pharmaceutical Technology Co., Ltd

Tel: 19033008971 13182942551 19331071838
Email: wang666xt@163.com
Country: China
ProdList: 429
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Lianyungang TengFa Biological Technology Co. Ltd

Tel: 0518-85475186 18705131893
Fax: 0518-85475186
Email: wang666xt@163.com
Country: China
ProdList: 351
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Country: China
ProdList: 544
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Tel: 1701086315
Fax: 1701086315@qq.com
Email: dexuanpharma@126.com
Country: China
ProdList: 9475
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

1332837-31-6, NUC-3373Related Search:

NUC-3373

5-FU analog prodrug NUC-3373

5-FU ANALOG PRODRUG NUC-3373; NUCLEOTIDE ANALOG NUC-3373; PHOSPHORAMIDATE-FUDR-MP PRODRUG NUC-3373

nucleotide analog NUC-3373

phosphoramidate-FUDR-MP prodrug NUC-3373

Fosifloxuridine nafalbenamide

L-Alanine, N-(2'-deoxy-5-fluoro-P-1-naphthalenyl-5'-uridylyl)-, phenylmethyl ester

NUC3373(Fosifloxuridine nafalbenamide)

inhibit,Fosifloxuridine nafalbenamide,anti-cancer,FdUMP,5-FU,5-fluorouracil,fluorodeoxyuridine,FUDR,5-fluorodeoxyuridine,monophosphate,Inhibitor,Thymidylate Synthase

benzyl (2S)-2-[({[(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(naphthalen-1-yloxy)phosphoryl)amino]propanoate

Benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate

Fosifloxuridine nafalbenamide, 10 mM in DMSO

1332837-31-6

C29H29FN3O9P